苯磺酸氨氯地平治疗社区高血压的临床疗效评价

Clinical Efficacy Evaluation of Amlodipine Besylate in Treatment of Hypertension in Community

目的:探究社区高血压患者应用苯磺酸氨氯地平治疗的效果。方法:选取2019年3月-2021年9月北京市房山区长阳镇社区卫生服务中心收治的126例高血压患者为研究对象,采用随机双盲法分为对照组和试验组,各63例。对照组采用硝苯地平缓释片治疗,试验组采用苯磺酸氨氯地平治疗。对比两组治疗前后血压(收缩压、舒张压),不良反应发生情况及血脂指标。结果:治疗前,两组收缩压、舒张压比较,差异无统计学意义(P>0.05);治疗后,试验组收缩压、舒张压均低于对照组,差异有统计学意义(P=0.000 0)。试验组不良反应发生率低于对照组,差异有统计学意义(P=0.008 3)。治疗前,两组总胆固醇、甘油三酯、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇水平比较,差异无统计学意义(P>0.05);治疗后,试验组总胆固醇、甘油三酯、低密度脂蛋白胆固醇水平低于对照组,高密度脂蛋白胆固醇水平高于对照组,差异有统计学意义(P=0.000 0)。结论:社区高血压患者应用苯磺酸氨氯地平治疗,具有显著疗效,值得临床应用并予以推广。

Objective:To explore the effect of amlodipine besylate in the treatment of hypertensive patients in the community.Methods:From March 2019 to September 2021,126 patients with hypertension who were treated in Community Health Service Center of Changyang Town of Fangshan District of Beijing were selected as the study subjects.According to randomized double blind method,the patients were divided into control group and experimental group,with 63 cases in each group.The control group was treated with nifedipine sustained-release tablets,and the experimental group was treated with amlodipine besylate.The blood pressure(systolic blood pressure,diastolic blood pressure) and blood lipid indexes before and after treatment,as well as the occurrence of adverse reactions were compared between the two groups.Results:Before treatment,there was no significant difference in systolic blood pressure and diastolic blood pressure between the two groups(P>0.05).After treatment,the systolic blood pressure and diastolic blood pressure in the experimental group were lower than those in the control group,and the difference was statistically significant(P=0.000 0).The incidence of adverse reactions in the experimental group was lower than that in the control group,and the difference was statistically significant(P=0.008 3).Before treatment,there were no significant differences in total cholesterol,triglycerides,low-density lipoprotein cholesterol,and high-density lipoprotein cholesterol between the two groups(P>0.05).After treatment,the levels of total cholesterol,triglycerides and low-density lipoprotein cholesterol in the experimental group were lower than those in the control group,and the levels of high-density lipoprotein cholesterol in the experimental group were higher than those in the control group,and the difference was statistically significant(P=0.000 0).Conclusion:The application of amlodipine besylate in the treatment of hypertensive patients in the community has significant efficacy and is worthy of clinical application and popularization.