去乙酰毛花苷注射液联合米力农对小儿重症肺炎合并心衰的疗效及安全性分析

Efficacy and Safety Analysis of Deslanoside Injection Combined with Milrinone in the Treatment of Severe Pneumonia Complicated with Heart Failure in Children

目的探讨去乙酰毛花苷联合米力农对小儿重症肺炎合并心衰的疗效。方法选取河南省中医院2021年1月至2022年1月收治的89例重症肺炎合并心衰患儿。随机分为对照组45例和观察组44例,对照组采用去乙酰毛花苷治疗,观察组加用米力农,均治疗5 d。比较两组治疗后的临床疗效、临床症状改善时间、临床指标,治疗前后的心功能指标[左室射血分数(LVEF)、左室收缩末径(LVDD)、房室瓣EA峰比值(E/A)、左室短轴缩短率(LVSF)]、炎性因子水平[白介素-6(IL-6)、白介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)]及不良反应。结果观察组临床疗效高于对照组,差异有统计学意义(P<0.05)。观察组各项临床症状改善时间均短于对照组,差异有统计学意义(P<0.05)。治疗后观察组心率低于对照组,差异有统计学意义(P<0.05),血氧饱和度和尿量高于对照组,差异有统计学意义(P<0.05)。治疗后观察组LVEF、E/A、LVSF高于对照组,差异有统计学意义(P<0.05),LVDD低于对照组,差异有统计学意义(P<0.05)。治疗后观察组血清IL-6、IL-8、TNF-α水平低于对照组,差异有统计学意义(P<0.05)。两组不良反应差异无统计学意义(P>0.05)。结论去乙酰毛花苷联合米力农疗效确切,可有效改善缓解重症肺炎合并心衰患儿临床症状,改善心功能,减轻机体炎症反应,且安全性较高。

Objective To investigate the effect of deslanoside combined with Milrinone on severe pneumonia complicated with heart failure in children.Methods A total of 89 children with severe pneumonia and heart failure admitted to Henan Hospital of Traditional Chinese Medicine from January 2021 to January 2022 were selected.The patients were randomly divided into the control group(45 cases)and the observation group(44 cases).The control group was treated with deslanoside,the milrinone was added to the observation group,and all patients were treated for 5 days.The clinical efficacy,improvement time of clinical symptoms,and clinical indicators of the two groups after treatment were compared.Cardiac function indexes[left ventricular ejection fraction(LVEF),left ventricular final systolic diameter(LVDD),atrioventricular valve EA peak ratio(E/A),left ventricular short axis shortening rate(LVSF)],infiammatory factor levels[interleukin-6(IL-6),interleukin-8(IL-8),tumor necrosis factor-α(TNF-α)]and adverse reactions were compared before and after treatment.Results The clinical effect of the observation group was higher than the control group,the difference was statistically significant(P<0.05).The improvement time of clinical symptoms in the observation group were shorter than that in the control group and the difference were statistically significant(P<0.05).After treatment,the heart rate of the observation group was lower than that of the control group,the difference was statistically significant(P<0.05),and the blood oxygen saturation and urine volume were higher than that of the control group,the difference was statistically significant(P<0.05).After treatment,LVEF,E/A,and LVSF in the observation group were higher than those in the control group,the difference was statistically significant(P<0.05),while LVDD was lower than that in the control group,the difference was statistically significant(P<0.05).After treatment,the serum levels of IL-6,IL-8,and TNF-αin the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion Deslanoside combined with milrinone has definite efficacy,can effectively improve and relieve the clinical symptoms of severe pneumonia complicated with heart failure,improve cardiac function,reduce infiammation,and have high safety.