针刺疗法联合ICS/LABA复合制剂治疗支气管哮喘慢性持续期的临床疗效

Clinical Efficacy of Acupuncture Therapy Combined with ICS/LABA Combination in the Treatment of Chronic Persistent Bronchial Asthma

目的评价针刺疗法联合ICS/LABA复合制剂治疗支气管哮喘慢性持续期的临床疗效。方法选取2020年1月至2021年5月睢县中医院中医呼吸科收治的82例支气管哮喘慢性持续期患者作为研究对象,采用随机数字表将其均分为对照组与观察组,对照组采用糖皮质激素及长效β2受体激动剂(ICS/LABA)复合制剂治疗(具体药物为舒利迭-沙美特罗替卡松粉吸入剂),观察组在药物治疗基础上给予针刺疗法。治疗一个月后比较两组患者的哮喘控制评分(ACT)、气道炎症性指标[呼出气一氧化氮(FeNO)、血清免疫球蛋白E(IgE)、诱导痰液嗜酸性粒细胞(EOS)占比]及肺功能指标[一秒率(FEV1/FVC)、最大呼气流速(PEF)、呼气容积(FEV1)]。结果经过治疗后,观察组ACT评分[(23.54±0.37)分]显著高于对照组[(20.07±0.42)分],差异有统计学意义(P<0.05)。观察组呼出气FeNO、血清IgE、诱导痰液EOS占比[(28.53±4.62)ppb、(62.58±16.93)IU/mL、(9.33±3.55)%]均显著优于对照组[(34.08±4.28)ppb、(80.73±20.56)IU/mL、(14.82±3.14)%],差异有统计学意义(P<0.05)。观察组FEV1/FVC、PEF、FEV1[81.25±3.04)%、(10.24±1.13)L/s、(3.08±0.29)L]显著优于对照组[(76.36±3.21)%、(8.87±1.03)L/s、(2.63±0.19)L],差异有统计学意义(P<0.05)。结论针刺疗法联合ICS/LABA复合制剂相对于单纯药物治疗,能更加有效地改善支气管哮喘慢性持续期患者的肺功能,缓解气道炎症反应,实现更好的哮喘控制效果。

Objective To evaluate the clinical efficacy of acupuncture therapy combined with ICS/LABA combination in the treatment of chronic persistent bronchial asthma.Methods A total of 82 patients with chronic persistent bronchial asthma who met the study criteria and were admitted to the Sui county Hospital of Traditional Chinese Medicine Hospital respiratory department from January 2020 to May 2021 were selected as study subjects,they were divided into a control group and an observation group using a random number table.The patients in the control group were treated with a combination of glucocorticoids and long-actingβ2 agonists(ICS/LABA)(the specific drug was sulindacin-salmeter inhalation),while the patients in the observation group received acupuncture therapy based on the drug treatment.One month after treatment,overall asthma control score(ACT),airway infiammatory parameters[exhaled nitric oxide(FeNO),serum immunoglobulin E(IgE),induced sputum eosinophil(EOS)]and lung function[one second(FEV1/FVC),maximum expiratory fiow rate(PEF),expiratory volume(FEV1)]were compared between two groups.Results After the therapeutic intervention,the ACT score(overall control level of asthma)of the patients in the observation group was(23.54±0.37),which was significantly higher than that of the control group(20.07±0.42),with significant difference(P<0.05);The FeNO,IgE and EOS of the patients in the observation group were(28.53±4.62)ppb,(62.58±16.93)IU/mL,and(9.33±3.55)%,respectively,were significantly better than those of the control group(34.08±4.28)ppb,(80.73±20.56)IU/mL,and(14.82±3.14)%,with significant differences(P<0.05);The FEV1/FVC,PEF,FEV1 in the observation group were(81.25±3.04)%,(10.24±1.13)L/s,(3.08±0.29)L,respectively,which were significantly better than those of the control group(76.36±3.21)%,(8.87±1.03)L/s,(2.63±0.19)L,respectively,with significant differences(P<0.05).Conclusion In patients with chronic persistent bronchial asthma relative to drug therapy alone,the treatment regimen of acupuncture therapy combined with ICS/LABA combination was more effective in improving lung function,while alleviating the airway infiammatory response and achieving better asthma control.