冠心舒通胶囊治疗冠心病慢性心力衰竭患者的疗效评价

Efficacy of Guanxin Shutong Capsule in the Treatment of Coronary Heart Disease Patients with Chronic Heart Failure

目的观察冠心舒通胶囊治疗冠心病慢性心力衰竭患者的临心血管病床疗效。方法选取2021年4月至2022年1月商丘市中心医院心内科收治的72例符合纳入标准的冠心病慢性心力衰竭住院患者作为研究对象,采用随机数字表法将其分为观察组(N=36)与对照组(N=36),其中对照组予以常规药物治疗,观察组在此基础上进行冠心舒通胶囊的治疗(患者3次/d,一次3粒,餐后口服),治疗4周。观察两组冠心病慢性心力衰竭患者的临床疗效、治疗前后患者的中医证候积分、6 min步行距离、生活质量评分、心脏超声指标、血浆C-反应蛋白(CRP)、血浆脑利钠肽前体(pro-BNP)、肝功能指标、肾功能指标、不良反应发生情况变化。并继续随访12周,比较两组患者心力衰竭恶化再入院率、严重不良心血管事件发生率。结果观察组患者治疗有效率明显高于对照组,差异有统计学意义(P<0.05)。观察组患者中医证候积分和生活质量评分明显低于对照组,差异有统计学意义(P<0.05)。观察组患者6 min步行距离明显高于对照组,差异有统计学意义(P<0.05)。观察组患者左室射血分数(LVEF)明显高于对照组,差异有统计学意义(P<0.05),而左心室收缩末内径(LVESD)、左心室收缩末内(LVEDD)明显低于对照组,差异有统计学意义(P<0.05)。两组患者肝、肾功能指标及不良反应发生率在治疗前后未见明显变化,差异无统计学意义(P>0.05)。与对照组患者的心力衰竭恶化再入院率和严重不良心血管事件发生率比较,观察组患者均降低,差异有统计学意义(P<0.05)。结论针对冠心病慢性心力衰竭患者采用冠心舒通胶囊治疗,能够改善中医证候症状和心功能各项指标,提升治疗效果,且安全性较高。

Objective To observe the clinical efficacy and safety of Guanxin Shutong Capsule in the treatment of coronary heart disease patients with chronic heart failure.Methods A total of 72 patients who met the inclusion criteria in the Cardiology Department of Cardiovascular Diseases of Shangqiu Central Hospital from April 2021 to January 2022 were used as study subjects,and the patients were divided into observation group(N=36)and control group(N=36)by random number table method.The control group was treated with conventional drugs,and the observation group was treated with Guanxin Shutong Capsule on the basis of the control group(oral 3 tablets once after meals,3 times a day),the course of treatment was 4 weeks.The clinical efficacy,TCM syndrome score,6-minute walking test,minnesota quality of life score,cardiac ultrasound indexes,Plasma C-reactive protein(CRP),Plasma brain natriuretic peptide precursors(Pro-BNP),liver function indexes,renal function indexes,and adverse reaction were recorded,continued follow-up of 12 weeks,the rate of rehospitalization and incidence of serious cardiovascular events in patients were observed.Results The total effective rate in observe group were obviously higher than that in control group,with significant difference(P<0.05).In the observation group,the TCM syndrome score and quality of life scores were significantly lower than those of the control group,indicating statistically significant differences(P<0.05).The 6-minute walking distance in observation group was significantly higher than that in control group,with significant difference(P<0.05).The Left ventricular ejection fraction(LVEF)in observation group was significantly higher than that in control group,with significant difference(P<0.05),while the End of inner diameter of left ventricular contraction(LVESD),End of inner diameter of left ventricular contraction(LVEDD)of patients were significantly lower than those in control group,with significant differences(P<0.05).The results show no differences in liver function indexes,renal function indexes,adverse effects rate between two groups before and after treatment(P>0.05).The incidence of serious cardiovascular events and the rate of rehospitalization in observation group were significantly lower than those in control group,with significant differences(P<0.05).Conclusion The treatment of coronary heart disease patients with chronic heart failure with Guanxin Shutong Capsule can improve the symptoms of TCM syndromes and cardiac function indicators,improve the therapeutic effect,and have high safety.