阿立哌唑治疗精神分裂症后抑郁的临床疗效及对患者生活、睡眠质量的影响

Clinical efficacy of aripiprazole in the treatment of post-schizophrenic depression and its influence on the quality of life and sleep of patients

目的 分析精神分裂症后抑郁患者接受阿立哌唑治疗的疗效及对其生活、睡眠质量的影响。方法 75例精神分裂症后抑郁患者,随机分为常规组(37例)与观察组(38例)。常规组患者接受利培酮治疗,观察组患者采取阿立哌唑治疗。比较两组患者临床疗效、阳性与阴性症状评分、抑郁评分、睡眠状况评分、睡眠质量评分及生活质量评分。结果 观察组患者治疗总有效率94.74%高于常规组的78.38%,差异有统计学意义(P<0.05)。治疗后,观察组患者阳性与阴性症状评分为(38.44±4.05)分,低于常规组的(43.48±3.83)分,差异有统计学意义(P<0.05)。治疗后,观察组患者抑郁评分为(38.44±4.05)分,低于常规组的(43.48±3.83)分,差异有统计学意义(P<0.05)。治疗后,观察组患者睡眠状况评分为(16.43±4.89)分、睡眠质量评分为(1.52±1.63)分,均低于常规组的(20.58±9.73)、(3.79±3.54)分,差异有统计学意义(P<0.05)。治疗后,观察组患者心理、精神、生理、环境、独立性、宗教信仰评分及总分均明显高于常规组,差异有统计学意义(P<0.05)。结论 阿立哌唑对精神分裂症后抑郁患者有着良好的治疗效果,可改善患者生活质量以及睡眠质量,可以考虑积极推广。

Objective To analyze the clinical efficacy of aripiprazole in the treatment of postschizophrenic depression and its influence on the quality of life and sleep of patients. Methods A total of 75 patients with post-schizophrenic depression were randomly divided into a conventional group(37 patients) and an observation group(38 patients). Patients in the conventional group were treated with risperidone, and patients in the observation group were treated with aripiprazole. The clinical efficacy, positive and negative symptom scores, depression scores, sleep status scores, sleep quality scores and quality of life scores in the two groups were compared. Results The total effective rate of treatment for patients in the observation group was 94.74%,which was higher than 78.38% in the conventional group, and the difference was statistically significant(P<0.05).After treatment, the positive and negative symptom scores of patients in the observation group were(38.44±4.05) points, which were lower than(43.48±3.83) points in the conventional group, and the difference was statistically significant(P<0.05). After treatment, the depression score of patients in the observation group was(38.44±4.05) points, which was lower than(43.48±3.83) points in the conventional group, and the difference was statistically significant(P<0.05). After treatment, the sleep status score of patients in the observation group was(16.43±4.89) points and the sleep quality score was(1.52±1.63) points, which were lower than(20.58±9.73)and(3.79±3.54) points in the conventional group, and the differences were statistically significant(P<0.05).After treatment, the psychological, spiritual, physical, environmental, independence, religious belief scores and total scores of patients in the observation group were significantly higher than those in the conventional group, and the differences were statistically significant(P<0.05). Conclusion Aripiprazole has a good therapeutic effect on patients with post-schizophrenic depression, and can improve the quality of life and sleep quality of patients,which can be actively promoted.