烯烃区域选择性氢二氟烷基化反应的研究进展

Recent advances in regioselective hydrodifluoroalkylation of alkenes

烯烃区域选择性的氢二氟烷基化反应,得益于基础化工原料烯烃具有廉价易得、来源丰富且富于结构多样性等特点,已成为构建在医药、农药和材料科学等领域的具有重要应用的二氟烷基化合物的一种直接和高原子经济性的方法.随着可见光催化策略的蓬勃发展和新型二氟烷基试剂的不断出现,这一研究领域在近年来取得了长足进展.本文旨在系统地介绍和总结烯烃区域选择性的反马氏和马氏氢二氟烷基化反应的最新研究进展,为相关研究人员提供参考和启示,也为新反应、新二氟烷基试剂和新催化策略的设计开发提供一些思路.

The regioselective hydrodifluoroalkylation of alkenes has been identified as a straightforward and highly atom-economical approach for synthesizing value-added difluoroalkylated molecules that have important applications in the pharmaceutical and agrochemical industries,as well as in the field of materials science.This is because olefins are structurally diverse raw materials that are inexpensive and easily obtainable from a wide range of sources.Recent years have witnessed significant progress in this field with the rapid development of visible-light catalysis and novel difluoroalkylating reagents.This article review summarizes the latest advances in the regioselective anti-Markovnikov and Markovnikov hydrodifluoroalkylation of various olefins,which provides an inspirational locale for researchers to engage.Herein,we supplement ideas for designing and developing new reactions,difluoroalkyl reagents,and catalytic strategies.