天然产物:农药新靶标与农药创制间的桥梁

Natural products:A bridge between new targets and novel pesticide discovery

农药的使用是控制作物病虫害、提高农作物产量的重要手段.天然产物及其衍生物是农药的重要来源,在杀虫、杀菌、植物生长调节、免疫调节等领域均发挥着重要作用.随着基因组学、蛋白组学、结构生物学和其他生物技术的发展,基于天然产物的农药靶标确证和基于靶标结构的新农药分子创制研究也得以飞速发展,使得“合理设计”在农药创制研究中的应用凸显.本文将通过案例,展示基于已知靶标的活性天然产物的发现,或基于天然产物的新农药靶标的确证,以及其后续新农药创制的研究进展,以阐释活性天然产物在新农药靶标与农药创制间的桥梁作用.

Pesticides are important tools to control crop diseases and pest hazards,guaranteeing the crop harvest.Natural products and their derivatives are major sources of novel pesticides and play indispensable roles in various fields,such as insecticide,fungicide,plant growth regulation,immune regulation and so on.In recent years,numerous fields of biotechnology have made great progress,like genomics,proteomics and structural biology.And thus,the identification of pesticide targets based on natural products and the creation of novel pesticide molecules based on target structures developed rapidly.The concept,rational design,received more attention in pesticide creation.In this article,the discovery of active natural products based on existed targets or novel targets verifying by natural products were demonstrated by several cases,and the subsequent progress in the development of new pesticides were also discussed.The cases explained the important role of natural products in bridging new targets and novel pesticides.