乙醇酸甲酯选择性氧化制备乙醛酸甲酯研究进展

Progress in synthesis of methyl glyoxylate by selective oxidation of methyl glycolate with molecular oxygen

乙醛酸甲酯在有机合成和化工生产中应用广泛,传统的制备方法存在成本高、效率低、易造成环境污染等缺点.乙醇酸甲酯是煤基合成气经草酸二甲酯加氢制乙二醇工艺的中间产物且可高选择性控制合成,以其为原料选择性氧化制备乙醛酸甲酯具有较好的工业应用前景,但目前为止,研究较为有限.本文综述了乙醛酸甲酯的应用、传统制备方法及乙醇酸甲酯氧化法的研究现状,也总结了相关醇类(如乙醇)选择性氧化制醛酮的研究进展.

Methyl glyoxylate is widely used in organic synthesis and chemical production.The application of traditional preparation methods is limited by high cost,low efficiency,and significant environmental pollution.During the coal to ethylene glycol process,methyl glycolate is produced as an intermediate product of the hydrogenation of dimethyl oxalate(DMO)to ethylene glycol.Methyl glycolate can be selectively obtained from DMO via hydrogenation,and therefore,has the potential to serve as raw material for methyl glyoxylate.However,only few studies have considered this process.Herein,the applications,traditional preparation methods,and state-of-the-art research progress of methyl glycolate oxidation are reviewed.Recent research on selective oxidation of related alcohols(such as ethanol)to aldehydes and ketones is also summarized.