铁死亡相关机制与子宫内膜癌

Ferroptosis-Related Mechanisms in Endometrial Cancer

子宫内膜癌是女性生殖系统三大恶性肿瘤之一,严重危害女性健康。近年研究发现,铁死亡在子宫内膜癌的发生、发展中起到重要作用。作为一种细胞程序性死亡方式,铁死亡与铁代谢、脂质代谢和氧化应激等生物过程密切相关。研究发现通过调控子宫内膜癌细胞铁代谢及氧化应激,可以促进癌细胞铁死亡,抑制肿瘤细胞增殖,且调控铁死亡的相关通路可以影响子宫内膜癌患者化疗敏感性,分析铁死亡相关基因表达可以预测子宫内膜癌患者预后。因此,铁死亡通路相关蛋白有望成为子宫内膜癌治疗新靶点。综述铁死亡的发生机制及其在子宫内膜癌的发生、治疗中的作用,并分析铁死亡相关分子作为一种新型的分子分型预测子宫内膜癌预后的潜在应用价值,为铁死亡在子宫内膜癌治疗领域中的应用提供新思路。

As one of the three female reproductive malignant tumors,endometrial cancer seriously endangers women′s health.Recent studies have revealed that ferroptosis is a critical factor in the initiation and progression of endometrial cancer.As a form of programmed cell death,Ferroptosis is closely related to multiple biological processes,such as iron metabolism,lipid metabolism and oxidative stress.It has been found that manipulation of iron metabolism and oxidative stress in endometrial cancer cells could lead to cancer cell ferroptosis and thus inhibit tumorigenesis.Additionally,regulation of ferroptosis-related pathway alters chemosensitivity of endometrial cancer patients,and comparative analysis of ferroptosis-related genes can be used for the prognosis prediction of endometrial cancer patients.Therefore,ferroptosis-related pathway proteins are promising targets for endometrial cancer treatment.This review briefly summarizes ferroptosis mechanisms and its role in the occurrence and treatment of endometrial cancer,and analyzes the potential application value of ferroptosis related molecules as a new type of molecular typing to predict the prognosis of endometrial cancer,and provides new ideas for the application of ferroptosis in the treatment of endometrial cancer.