尿路上皮体细胞突变在膀胱肿瘤发生和复发中作用的研究进展

Research progress on the role of urothelial somatic mutations in the occurrence and recurrence of bladder cancer

膀胱肿瘤具有高发病率、高复发率等特点,但其发生和发展,特别是易复发的具体机制仍不明了。本文从膀胱癌分子特征、尿路上皮体细胞突变景观、驱动基因及突变特征等方面来阐述尿路上皮体细胞突变在膀胱肿瘤发生、复发中的作用及机制,并对下一步的研究方向进行展望。

Bladder cancer is characterized by high incidence and high recurrence;however,the mechanism of pathogenesis,especially of recurrence is still unclear.This paper reviews the molecular characteristics of bladder cancer,urothelial somatic mutation,driver genes and mutation characteristics,and prospects the future research directions.