针刺预防治疗中重度季节性变应性鼻炎:随机对照试验

Acupuncture for prevention of moderate to severe seasonal allergic rhinitis: a randomized controlled trial

目的:观察针刺预防治疗中重度季节性变应性鼻炎(SAR)的临床疗效。方法:将105例中重度SAR患者随机分为观察组(53例,脱落3例)和对照组(52例,脱落4例)。观察组于患者发作期前4周予针刺预防治疗,穴取印堂、迎香、合谷、足三里、风池、肺俞等,隔日1次,每周3次,连续治疗4周;对照组发作期前不予任何干预,两组发作期均可适当予应急药物。于发作期结束后记录两组患者发作率,观察两组患者治疗前及治疗后发作期第1、2、4、6周的鼻结膜炎患者生活质量问卷(RQLQ)及鼻症状总分(TNSS)评分,于发作期第1~6周记录两组应急药物评分(RMS)。结果:观察组发作率为84.0%(42/50),低于对照组的100.0%(48/48,P<0.05)。治疗后,观察组发作期各时间点RQLQ、TNSS评分均较治疗前降低(P<0.01),且均低于对照组(P<0.01);观察组发作期各时间点RMS评分均低于对照组(P<0.05,P<0.01)。结论:针刺预防治疗可在一定程度上降低中重度SAR发作率,减轻患者发作症状,提高患者生活质量,减少应急药物使用量。

Objective To observe the clinical efficacy of acupuncture for prevention of moderate to severe seasonal allergic rhinitis. Methods A total of 105 patients with moderate to severe seasonal allergic rhinitis were randomly divided into an observation group(53 cases, 3 cases dropped off) and a control group(52 cases, 4 cases dropped off). The patients in the observation group were treated with acupuncture at Yintang(GV 24+), Yingxiang(LI 20), Hegu(LI 4),Zusanli(ST 36), Fengchi(GB 20), Feishu(BL 13), etc. 4 weeks before the seizure period, once every other day, 3 times a week for 4 weeks. The patients in the control group were not given any intervention before the seizure period. Emergency drugs can be given appropriately during the seizure period in both groups. After seizure period, the seizure rate was recorded in the two groups;before treatment and on week 1, 2, 4, 6 of seizure period after treatment, the rhinoconjunctivitis quality of life questionnaire(RQLQ) score and total nasal symptom score(TNSS) were observed in the two groups;the rescue medication score(RMS) was recorded on week 1-6 of seizure period in the two groups. Results The seizure rate of the observation group was 84.0%(42/50), which was lower than 100.0%(48/48) in the control group(P<0.05). After treatment, the scores of RQLQ and TNSS at each time point of seizure period were decreased compared with before treatment in the observation group(P<0.01), which were lower than the control group(P<0.01). The RMS score at each time point of seizure period in the observation group was lower than the control group(P<0.05, P<0.01). Conclusion Acupuncture can reduce the incidence of moderate to severe seasonal allergic rhinitis, relieve the symptoms, improve the quality of life and reduce the use of emergency drugs.