电针调控缺血性脑卒中后学习记忆障碍机制研究进展

Research progress on the modulation mechanism of electroacupuncture for learning and memory impairment after ischemic stroke

电针可能通过调控磷脂酰肌醇-3-激酶(PI3K)/蛋白激酶B(Akt)信号通路、环磷酸腺苷(cAMP)依赖的蛋白激酶A(PKA)/cAMP反应元件结合蛋白(CREB)信号通路、神经生长因子(NGF)/酪氨酸激酶受体A(TrkA)信号通路、Janus激酶2(JAK2)/信号转导和转录激活因子3(STAT3)信号通路、Notch信号通路、促红细胞生成素产生肝细胞(Eph)/肝配蛋白(ephrin)信号通路发挥治疗缺血性脑卒中后学习记忆障碍作用,应进一步探讨各通路相互作用对缺血性脑卒中学习记忆功能的影响。

Electroacupuncture may play a role in treatment of learning and memory impairment after ischemic stroke by regulating phosphatidylinositol-3-kinase(PI3K)/protein kinase B(Akt) signaling pathway, cyclic adenosine monophosphate(cAMP)-dependent protein kinase A(PKA)/cAMP response element binding protein(CREB) signaling pathway, nerve growth factor(NGF)/tyrosine kinase-A(TrkA) signaling pathway, Janus kinase 2(JAK2)/signal transducer and activator of transcription 3(STAT3) signaling pathway, Notch signaling pathway, erythropoietin-producing hepatocyte(Eph)/ephrin signaling pathway. The interactions among these pathways should be further explored in treatment of learning and memory impairment after ischemic stroke.