老药新用研究策略与应用(2)——基于新适应证发现的研究策略与应用

Drug Repurposing(2):Strategies and Applications on Discovering New Indications

近年来,“老药新用”概念被用于许多临床上正用于治疗疾病的药物,以及曾经或正处于临床前或临床试验中的候选药物。历史上及当前一系列著名的药物重定位应用,推动了基于“老药新用”的药物研发,并使之应用于新的适应证。该文基于新适应证的发现,论述新药研究中药物重定位,讨论了一系列新适应证的“老药新用”的科学研究基础及关键研究策略,包括根据药物现有基本作用机制发现新适应证,根据药物副作用发现新适应证,以及基于药物新作用机制发现新适应证等。

In recent years,many clinically applied drugs,as well as drug candidates that had been or were in preclinical or clinical trials,had been redeveloped for new indications.The success of repurposing of a series of famous drugs had promoted the repurposing developments.In the previous article,the drug repurposing study based on clinical treatment needs had been discussed.In this paper,we reviewed drug repurposing studies based on the discovery of new indications.We reviewed repurposing strategies,including the discovery of new indications based on the existing basic action mechanism of drugs,the discovery of new indications based on the side effects of drugs,and the discovery of new indications based on the new action mechanism of drugs.