高尿酸联合BNP、CRP、HCY可预测急性心肌梗死患者主要不良心血管事件

High uric acid combined with BNP,CRP and HCY can predict major adverse cardiovascular events in patients with acute myocardial infarction

目的:探讨急性心肌梗死患者高血尿酸(HSUA)与B型钠尿肽(BNP)、C反应蛋白(CRP)、同型半胱氨酸(HCY)及主要不良心血管事件(MACE)的相关性。方法:选取急性心肌梗死患者123例,根据血尿酸(SUA)水平分为实验组(>420μmoI/L)和对照组(≤420μmoI/L)。分析2组临床基本资料特征及HSUA与急性心肌梗死后MACE的相关性。结果:与对照组比较,实验组血SUA、BNP、CRP、HCY水平更高(P<0.05或P<0.01)。Spearman相关性分析显示HSUA与BNP、CRP、HCY呈正相关(r=0.256、0.237、0.374,P均<0.01)。Kaplan-Meier生存分析示1年随访期实验组累积MACE发生率高于对照组(86.5%vs 66.3%,P<0.05)。多因素Cox分析结果示,HSUA和BNP是影响MACE发生的独立预测因子(HR=33.878、13.361,95%CI:1.077~1065.761、1.319~135.330,P均<0.05)。结论:急性心肌梗死患者HSUA与BNP、CRP、HCY有关,是急性心肌梗死后MACE发生的一个独立预测因子。

Objective:To investigate the correlation of hyperuricemia with B-type natriuretic peptide(BNP),C-reactive protein(CRP),homocysteine(HCY)and major adverse cardiovascular events(MACE)in patients with acute myocardial infarction.Methods:Totally,123 cases of acute myocardial infarction were seleted,and divided into experimental group(>420μmoI/L)and control group(≤420μmoI/L)according to the level of serum uric acid(SUA).The clinical characteristics of the two groups and the correlation between HSUA and MACE were analyzed after acute myocardial infarction.Results:Compared with the control group,the levels of SUA,BNP,CRP and HCY were significant increased in the experimental group(P<0.05 or P<0.01).Spearman correlation analysis showed that high HSUA was correlated with BNP,CRP and HCY positively(r=0.256,0.237,0.374,all P<0.01).Kaplan-Meier survival analysis showed that the cumulative incidence of MACE in the experimental group was higher than in the control group(86.5%vs 66.3%,P<0.05).Multivariate Cox analysis showed that HSUA and BNP were independent predictors of MACE(HR=33.878,13.361;95%CI:1.077-1065.761,1.319-135.330;P<0.05).Conclusion:HSUA is associated with BNP,CRP and HCY in patients with acute myocardial infarction,and it is an independent predictor of MACE in patients with acute myocardial infarction.