饮食干预与炎症性肠病相关性的中西医研究进展

Research progress of correlation study on diet intervention and inflammatory bowel disease

炎症性肠病是一种主要累及胃肠道的慢性非特异性炎症疾病,包括溃疡性结肠炎和克罗恩病。炎症性肠病的病因病机尚未明确,目前普遍认为其发病机制为环境、免疫因素共同作用于易感机体。饮食作为环境因素中的重要环节,与炎症性肠病的疾病进程密切相关,其通过影响肠道微生物代谢、调控肠道黏膜免疫达到或延长疾病缓解。但饮食对炎症性肠病的治疗及预防作用往往被低估,目前炎症性肠病的研究热点集中在药物治疗,而饮食干预简、便、廉、验,对炎症性肠病的防治具有重要临床意义。中医强调“治未病”,倡导“药食同源”,重视体质,对炎症性肠病维持缓解和预防复发具有突出优势和广阔的研究前景。

Inflammatory bowel disease(IBD)is a chronic,nonspecific inflammatory disease that primarily affects the gastrointestinal tract,including ulcerative colitis(UC)and Crohn disease(CD).While the etiology of IBD has not been clarified,the changes in environmental factors combined with an aberrant immune response in genetically predisposed individuals are putatively implicated in the pathogenesis of IBD.As an important component of environmental factors,diet is closely associated with the onset and course of IBD,which may facilitate achieving or prolonging remissions by influencing the gut microbiota and intestinal mucosal immunity.However,the therapeutic and preventive effect of diet is often underestimated,the current study hotspot of IBD is drug treatment.Whereas dietary interventions are attainable and affordable,which plays a pivotal role in the treatment of IBD,Traditional Chinese Medicine attaches great importance to preventative treatment,emphasizes the homology of medicine and food,and sets great store by individuality,which shows outstanding advantages and broad research prospects for maintaining remission and preventing recurrence.