红玉赔赈方治疗脓毒症血流动力学障碍的临床研究

Clinical Study on the Treatment of Hemodynamic Disorders in Sepsis by Hongyu Peizhen Prescription

目的观察红玉赔赈方对脓毒症患者血流动力学指标的影响及临床疗效。方法将62例脓毒症患者随机分为两组,对照组给予西医常规治疗,治疗组在西医常规治疗的基础上予以连续7 d服用红玉赔赈方。使用无创心输出量监测仪(ICON)监测两组患者血流动力学指标变化,并记录序贯性器官衰竭(SOFA)评分、急性生理与慢性健康状况Ⅱ(APACHEⅡ)评分、中医证候积分等,做统计分析。结果治疗后,对照组心排血量(CO)明显下降(P<0.05),治疗组治疗期间CO基本持平;治疗组外周血管阻力(SVR)下降,系统血管阻力指数(SVRI)上升(P>0.05);治疗组中医证候积分明显下降(P<0.05);治疗组总有效率为70.00%,高于对照组的43.75%(P<0.05)。结论红玉赔赈方联合西医常规治疗能够稳定脓毒症患者心脏泵功能,降低心脏后负荷,改善临床症状,促进患者康复。

Objective:To observe the effect of Hongyu Peizhen Prescription on the hemodynamics of sepsis.Methods:A total of 62 patients with sepsis were randomly divided into two groups.The control group was given conventional western medical treatment,and the treatment group was given Hongyu Peizhen Prescription for 7 consecutive days on top of conventional western medical treatment.The cardiac output changes of the two groups were monitored using a non-invasive cardiac output monitor(ICON),and the SOFA score,APACHEⅡscore and TCM evidence score were recorded and statistically analyzed.Results:After treatment,cardiac output decreased significantly in the control group(P<0.05)and remained basically the same during treatment in the treatment group;system vascular resistance decreased and systemic vascular resistance index increased in the treatment group(P>0.05);the TCM syndrome score decreased significantly in the treatment group(P<0.05);the total effective rate was 43.75%in the control group and 70.00%in the treatment group,and the difference was statistically significant(P<0.05).Conclusion:Hongyu Peizhen Prescription combined with conventional western medicine treatment can stabilize cardiac pump function,reduce cardiac afterload,improve clinical symptoms and promote patients’recovery in sepsis patients.