岐黄针治疗非痴呆型血管认知功能障碍临床研究

Clinical Study of Qihuang-Needle Therapy in Treatment of VCIND

目的:观察岐黄针治疗非痴呆型血管认知功能障碍(VCIND)的临床疗效,为VCIND提供更丰富的治疗手段。方法:纳入合格受试者共90例,随机分为岐黄针组、针刺组与对照组,各30例,对照组仅采取脑功能认知障碍康复训练,2次/周,30 min/次,针刺组在对照组基础上联用普通针刺,岐黄针组在对照组的基础上联用岐黄针疗法,选取百会、厥阴俞、印堂与肾俞4个穴位,均为2次/周,4周后比较两组蒙特利尔认知评估量表(MoCA)评分、简明精神状态检查量表(MMSE)评分、日常生活能力量表(ADL)评分、中医证候积分及超敏C反应蛋白(hs-CRP)浓度。结果:与治疗前比较,治疗后各组MoCA、MMSE及ADL评分均较前升高,中医证候积分、hs-CRP浓度均较前降低,差异具有统计学意义(P<0.05);治疗后与对照组及针刺组比较,岐黄针组在改善MoCA、MMSE、ADL评分、中医证候积分和抑制炎症反应方面效果更显著,差异具有统计学意义(P<0.05),且总有效率为100%(30/30),高于针刺组的90%(27/30)及对照组的83.33%(25/30)。结论:岐黄针联合脑功能认知障碍康复训练可以显著改善患者的认知能力和生活质量,疗效确切,操作安全,值得临床推广使用。

Objective:To observe the clinical effect of Qihuang-needle therapy in treating vascular cognitive impairment no dementia(VCIND),in order to provide more treatment methods for the disease.Methods:90 patients who met the diagnosis criteria were randomly divided into the Qihuang-needle group(n=30),the acupuncture group(n=30)and the control group(n=30).Cognitive dysfunction rehabilitation training(30 minutes each time,twice a week)was applied in each group;on which basis,the acupuncture group was treated with common acupuncture,and the Qihuang-needle group was treated with needling Baihui(DU20),Jueyinshu(BL14),Yintang(EX-HN3)and Shenshu(BL23),2 times a week for 4 weeks.The scores of MoCA,MMSE,ADL,TCM symptoms and the level of hs-CRP were compared between the two groups after four weeks of treatment.Results:The scores of MoCA,MMSE and ADL were higher(P<0.05),and the score of TCM symptoms and the level of hs-CRP were lower after the treatment than those before the treatment in the two groups(P<0.05).Compared with the control group and the acupuncture group,the Qihuang-needle group had more significant effects in improving the scores of MoCA,MMSE,ADL and TCM symptoms and in inhibiting inflammation(P<0.05).The total effective rate was 100%(30/30)in the Qihuang-needle group,which was higher than 90%(27/30)in the acupuncture group and 83.33%(25/30)in the control group(P<0.05).Conclusion:Qihuang-needle combined with cognitive dysfunction rehabilitation training can significantly improve cognitive dysfunction and life quality with its significant clinical effect and safety operation,which is worthy to be popularized in clinical practice.