表观遗传学在子宫内膜异位症中的研究进展

Research Progress on Epigenetics in Endometriosis

表观遗传学是指在基因序列未发生改变的情况下,基因表达和功能发生可遗传的变化,其机制包括DNA甲基化、组蛋白修饰和非编码RNA等。子宫内膜异位症是一种影响育龄期妇女生育和健康的良性妇科疾病,其具体发病机制尚不明确。近年来研究发现表观遗传学在子宫内膜异位症的发生发展中起重要作用,本文就表观遗传学在子宫内膜异位症中的调控机制及应用的研究进展进行综述。

Epigenetics refers to heritable changes in gene expression and function without alterations in gene sequences,including DNA methylation,histone modification,and non-coding RNAs.Endometriosis is a benign gynecological disease that affects the fertility and health of reproductive-age women,the etiology of which remains unclear.The recent studies have demonstrated that epigenetics plays a key role in the occurrence and development of endometriosis.This article reviews the research progress in the regulatory mechanism and application of epigenetics in endometriosis.