坤泰胶囊治疗女性更年期失眠伴焦虑及抑郁的临床疗效观察

Clinical Effect of Kuntai Capsule on Insomnia with Anxiety and Depression in Female Menopause

目的:探究坤泰胶囊治疗女性更年期失眠伴焦虑及抑郁的临床疗效。方法:选取2021年1月至2021年12月福建省南平邵武市卫闽卫生院收治的女性更年期失眠伴焦虑及抑郁患者84例作为研究对象,按照随机数字表法随机分为对照组和观察组,每组42例。对照组患者采用艾司唑仑治疗,观察组患者采用坤泰胶囊治疗,比较2患者的临床治疗效果。结果:观察组治疗总有效率95.24%,对照组治疗总有效率80.95%,2组比较差异有统计学意义(P<0.05);治疗前,2组患者性激素指标比较,差异均无统计学意义(均P>0.05);治疗12周后,2组性激素指标均有改善,观察组黄体生成素(LH)、促卵泡素(FSH)水平低于对照组,雌二醇(E 2)水平高于对照组,2组比较差异均有统计学意义(均P<0.05);治疗前,2组患者焦虑自评量表(SAS)评分及抑郁自评量表(SDS)评分比较,差异均无统计学意义(均P>0.05);经12周规范治疗后,2组患者SAS评分及SDS评分均下降,观察组SAS评分及SDS评分均低于对照组,2组比较差异均有统计学意义(均P<0.05);治疗前,2组患者匹兹堡睡眠质量指数(PSQI)评分比较,差异无统计学意义(P>0.05);治疗后,2组患者PSQI评分均下降,观察组PSQI评分低于对照组,2组比较差异有统计学意义(P<0.05);观察组不良反应发生率7.14%,对照组不良反应发生率11.90%,2组比较差异无统计学意义(P>0.05)。结论:应用坤泰胶囊治疗女性更年期失眠伴焦虑及抑郁疾病,可有效改善患者症状,提升睡眠质量,缓解焦虑、抑郁情绪,具有推广应用价值。

Objective:To explore the clinical efficacy of Kuntai Capsule in the treatment of female menopause insomnia with anxiety and depression.Methods:A total of 84 female menopausal insomnia patients with anxiety and depression were selected from January 2021 to December 2021 in Shaowu Weimin Hospital.The method of grouping was random number table method,including 42 cases in control group(treated with estazolam)and 42 cases in observation group(treated with Kuntai Capsule).The application effects of the two treatment plans in patients were compared.Results:The total effective rate of observation group(95.24%)was significantly higher than that of control group(80.95%),and the difference was significant(P<0.05).There was no difference in sex hormone index between control group and observation group before treatment(P s>0.05).After 12 weeks of treatment,the sex hormone indexes of the two groups were significantly improved.Compared with control group,the levels of luteinizing hormone(LH)and follicle stimulating hormone(FSH)in observation group were lower,and the level of estradiol(E 2)was higher(P s<0.05).Before treatment,there was no statistically significant difference in the scores of Self-rating Anxiety Scale(SAS)and Self-rating Depression Scale(SDS)between control group and observation group(P>0.05).After 12 weeks of standardized treatment,the SAS score and SDS score of patients in the two groups decreased,and the SAS score and SDS score in the observation group were lower than those in the control group.The difference between the two groups was statistically significant(P s<0.05).There was no significant difference in Pittsburgh Sleep Quality Index(PSQI)score between control group and observation group before treatment(P>0.05).After treatment,the sleep quality of patients in the two groups was improved,and the PSQI score of observation group was lower than that of control group(P<0.05).The incidence of adverse reactions in observation group(7.14%)and control group(11.90%)had no significant difference(P>0.05).Conclusion:The application of Kuntai Capsule in the treatment of female menopause insomnia with anxiety and depression can effectively improve the symptoms of patients,improve the quality of sleep,relieve anxiety and depression,and has the value of promotion.