白藜芦醇对阿尔茨海默病调控的研究进展

Research Progress on the Regulation of Resveratrol on Alzheimer’s Disease

阿尔茨海默病(Alzheimer’s disease,AD)是一种常见的衰老所致的神经退行性疾病,AD的发生主要表现为个体进行性记忆与认知功能下降,以及无法自主行动甚至死亡的发生。其病理特征主要为β-淀粉样蛋白、神经纤维缠结、神经元炎症、细胞自噬功能受损、线粒体功能障碍、突触可塑性和功能下降等。目前AD的药物治疗策略主要包括乙酰胆碱酯酶抑制剂、N-甲基-D-天冬氨酸受体拮抗剂等,而药物性治疗大多数只能改善症状,并不能实质性延缓AD的发展。随着对天然产物的深入研究,白藜芦醇(resveratrol,RSV)作为沉默信息调节因子2相关酶1(silent mating type information regulation 2 homolog-1,Sirt1)激活剂,主要通过调节Sirt1相关信号通路提高神经细胞自噬水平、改善线粒体质量、抑制神经性炎症,在AD防治中显示出潜在的治疗价值。因此,本文对RSV在AD的预防与治疗中的作用与机制相关研究进行系统性梳理与总结,可为后续RSV对AD的精准靶向预防与治疗或其他药物开发提供参考。

Alzheimer’s disease(AD),a common aging-related neurodegenerative diseases,is an important inducement of cognitive,memory and mental disorders in the elderly.The major pathological characteristics of AD include amyloidβ-protein(Aβ),neurofibrillary tangles,neuroinflammation,impaired autophagy,and mitochondrial dysfunction and decreased synaptic plasticity and function.The pharmacological treatment strategies for AD are focused on acetylcholinesterase inhibitors and N-methyl-D-aspartic acid(NMDA)receptor antagonists.However,most medications for AD can only alleviate symptoms,not substantially delay the development of AD.With the in-depth studies of natural products,it is found that resveratrol(RSV),which is an activator of silent mating type information regulation 2 homolog-1(Sirt1),can activate autophagy in nerve cells,improve mitochondrial quality and inhibit neuroinflammation by regulating Sirt1-related signaling pathways,thereby having the potential prevent and treat AD.In this article,the studies on the role and mechanism of action of RSV in the prevention and treatment of AD are summarized,which will provide a reference for follow-up studies on RSV in the targeted prevention and treatments of AD,and the development of new anti-AD agents.