食源性生物活性肽对2型糖尿病的干预作用及其机制研究进展

Ameliorative Effect and Mechanism of Food-Derived Bioactive Peptides against Type 2 Diabetes Mellitus:A Review

2型糖尿病属于非胰岛素依赖性糖尿病,全世界每年有数百万人患2型糖尿病或成为潜在患者。食源性活性肽不仅具有基本的营养优势,而且更易被机体吸收,有研究证实生物活性肽可以抑制与2型糖尿病相关的代谢酶活力,促进肠促胰岛素分泌,改善胰岛素抵抗,因此可以作为有效管理该疾病的功能性食品或药物。本文综述了食源性生物活性肽的特性和来源,以及目前其关于调节血糖作用机制的研究进展,归纳了食源性代谢酶调节剂的相关研究,以期为食源性生物活性肽的进一步研究提供参考。

Type 2 diabetes mellitus is also called non-insulin-dependent diabetes mellitus.Every year,millions of people around the world suffer from type 2 diabetics or become potential patients.Food-derived bioactive peptides not only provide essential nutritional benefits,but also are more easily absorbed by the body.Previous studies have shown that bioactive peptides can inhibit the activity of metabolic enzymes associated with type 2 diabetes,promote insulin secretion and improve insulin resistance,making them functional foods or drugs for effective management of this disease.In order to provide a reference for further research on food-derived bioactive peptides,this paper reviews the properties and sources of foodderived bioactive peptides and the state of the art in research on the regulatory mechanism of food-derived bioactive peptides on blood glucose levels,and it summarizes the studies on food-derived metabolic enzyme modulators.In order to provide a reference for the innovation of food-derived bioactive peptides.