脂多糖致奶牛糖脂代谢异常研究进展

Research Progress on Abnormal Glucose and Lipid Metabolism in Dairy Cows Induced by Lipopolysaccharide (LPS)

脂多糖(LPS)是革兰阴性菌细胞壁的主要成分,广泛存在于环境中,可诱导机体炎症反应,与奶牛的多种疾病相关。环境和疾病等因素引起机体LPS水平升高,LPS与巨噬细胞、中性粒细胞和上皮细胞等作用,激活NF-κB和MAPKs信号通路,释放炎症因子,改变机体糖脂代谢相关激素和脂肪因子水平,进而影响糖脂代谢,造成奶牛2型糖尿病、酮病、脂肪肝和肥胖等代谢性疾病。本文综述了LPS与炎症反应和糖脂代谢相互作用关系及其导致糖脂代谢异常作用机制,为LPS致奶牛糖脂代谢异常机理研究提供参考。

Lipopolysaccharide(LPS) is the main component of the cell wall of Gram-negative bacteria and widely exists in the environment. It can induce inflammatory response and is related to various diseases of dairy cows. Environmental and disease factors cause the increase of LPS level in the body. LPS acts with macrophages, neutrophils and epithelial cells, activates NF-κB and MAPKs signaling pathways, releases inflammatory factors, changes the levels of hormones and adipokine related to glucose and lipid metabolism, and further affects glucose and lipid metabolism, resulting in metabolic diseases such as type 2 diabetes, ketosis, fatty liver and obesity in dairy cows. This paper reviews the interaction between LPS and inflammatory response, glucose and lipid metabolism and the mechanism of abnormal glucose and lipid metabolism, which provides a reference for the mechanism of abnormal glucose and lipid metabolism induced by LPS in dairy cows.