熟地黄药效物质基础研究进展

Research progress on effective constituents in Radix Rehmanniae Praeparata

熟地黄为玄参科植物地黄Rehmannia glutinosa新鲜或干燥块根的炮制加工品,具有补血滋阴、益精填髓等功效。熟地黄是中药“滋阴”作用最具代表的药味之一,也被称之为“至阴之药”。熟地黄配伍相关经典方剂被广泛应用于治疗肝肾阴虚导致的各种临床疾病,包括糖尿病相关疾病、神经系统疾病、骨关节炎相关疾病、妇科相关疾病等。基于近年来发表的文献,对熟地黄化学成分、活性成分的药理作用、方剂配伍条件下的药效物质的基础研究进展进行综述,以期为熟地黄的深入研究提供参考。

Shudihuang(Radix Rehmanniae Praeparata) is the processed product of the Rehmannia glutinosa of the genus Ginseng family. Its main functions are to nourish blood, nourish yin, and benefit the essence and fill the marrow. Radix Rehmanniae Praeparata is one of the most representative medicinal flavors of traditional Chinese medicine for “nourishing yin”, and it is also known as “medicine of supreme yin”. Classical prescriptions containing Radix Rehmanniae Praeparata widely used to treat various clinical diseases caused by liver and kidney Yin deficiency, including diabetes-related diseases, nervous system diseases, osteoarthritis-related diseases, gynecological-related diseases, etc. Based on the literature published in recent years, the studies on chemical constituents,pharmacological actions of effective constituents, and pharmacodynamic material basis under the condition of prescription compatibility were reviewed in this paper, to provide reference for the further research of Radix Rehmanniae Praeparata.