半乳糖凝集素-3及糖基化终末产物对糖尿病肾病的影响

The Effects of Galectin-3 and Glycation End Products on Diabetic Kidney Disease

糖尿病肾病(DKD)是糖尿病患者常见的并发症,也是其主要死因之一。然而DKD起病隐匿,因此需要早发现、早治疗。在DKD的发病机制中,晚期糖基化终末产物(AGEs)有重要作用,而半乳糖凝集素-3(Gal-3)作为AGEs的一个受体,其与DKD的关系仍存在争议。故本文对AGEs及Gal-3对DKD的影响机制进行综述,以期为临床治疗提供参考。

Diabetic kedney disease(DKD) is a common complication and one of the main causes of death of diabetic mellitus patients. However, the onset of DKD is insidious, early detection and treatment is necessary for it. Advanced glycation end products(AGEs) play an important role in the pathogenesis of DKD. Galectin-3(Gal-3), as a receptor of AGEs, its relationship with DKD is still controversial. Therefore, this article reviews AGEs and Gal-3 on DKD in order to provide reference for clinical treatment.