四物牵正散联合针刺治疗风寒袭络型急性期周围性面瘫临床研究

Clinical Study on Four Substance Symmetry-Correcting Powder Combined with Acupuncture in Treating Acute Peripheral Facial Paralysis with Syndrome of Wind and Cold Attacking Collaterals

目的:观察四物牵正散联合针刺治疗风寒袭络型急性期周围性面瘫的临床疗效。方法:将86例风寒袭络型急性期周围性面瘫患者按照随机数字表法分为对照组和试验组,每组各43例。对照组给予四物牵正散治疗,试验组在对照组治疗的基础上联合针刺疗法。比较两组患者的临床疗效、不良反应发生率及治疗前后面神经功能评分、面部残疾指数躯体功能(facial disability index physical function, FDIP)评分、面部残疾指数社会功能(facial disability index social function, FDIS)评分、中医证候积分、FaCE量表评分、免疫功能水平(CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))变化情况。结果:对照组有效率为81.39%,试验组有效率为93.02%,两组患者有效率比较,差异具有统计学意义(P<0.05)。两组患者治疗后面神经功能评分、FDIP评分、FDIS评分高于本组治疗前,中医证候积分较低于本组治疗前,且治疗后组间比较,差异具有统计学意义(P<0.05)。两组患者治疗后FaCE量表各项评分高于本组治疗前,且治疗后试验组高于对照组,差异具有统计学意义(P<0.05)。两组患者治疗后CD3^(+)、CD4^(+)及CD4^(+)/CD8^(+)高于治疗前,CD8^(+)低于本组治疗前,且治疗后组间比较,差异具有统计学意义(P<0.05)。试验组不良反应发生率低于对照组,差异具有统计学意义(P<0.05)。结论:四物牵正散联合针刺治疗风寒袭络型急性期周围性面瘫患者,能够调节患者免疫功能,改善临床症状,且不良反应较低。

Objective: To observe the clinical efficacy of Four Substance Symmetry-Correcting Powder combined with acupuncture on acute peripheral facial paralysis with syndrome of wind and cold attacking collaterals.Methods: A total of 80 patients with acute peripheral facial paralysis with syndrome of wind and cold attacking collaterals were randomly divided into the control group and the experimental group, with 43 cases in each group.The control group was treated with Four Substance Symmetry-Correcting Powder, and the experimental group was additionally treated with acupuncture on the basis of the control group.The clinical efficacy, incidence of adverse reactions, the changes of the neurological function score, facial disability index physical function(FDIP) score, facial disability index social function(FDIS) score, TCM syndrome score, FaCE scale score, and immune level before and after treatment were compared between the two groups.Results: The effective rate in the control group was 81.39% and 93.02% in the experimental group.The difference between the two groups was statistically significant(P<0.05).After treatment, the neurological function score, FDIP score and FDIS score of the two groups were higher than those before treatment, while the TCM syndrome score was lower than that before treatment, and all the differences between the two groups were statistically significant(P<0.05).After treatment, all the scores of the two groups of patients on the FaCE scale were higher than those before treatment, and the experimental group′s scores were higher than those the control group, and all the differences were statistically significant(P<0.05);All the scores of the two groups of patients on the FaCE scale were higher than those before treatment, and the experimental group′s scores were higher than those of the control group, and all the differences were statistically significant(P<0.05).The CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)of patients in the two groups were higher than those before treatment, while the CD8^(+)was lower than that before treatment, and all the differences between the two groups were statistically significant(P<0.05).The incidence of adverse reactions in the experimental group was lower than that in the control group, and the difference was statistically significant(P<0.05).Conclusion: Four Substance Symmetry-Correcting Powder combined with acupuncture can regulate the immune function of patients with acute peripheral facial paralysis with syndrome of wind and cold attacking collaterals, improve the clinical symptoms, and have low adverse reactions.