脂肪因子Adipsin与2型糖尿病相关性的研究进展

Research progress on relationship between adipokines Adipsin and type 2 diabetes mellitus

2型糖尿病(type 2 diabetes mellitus,T2DM)在全球范围内的盛行对公众健康造成了巨大影响,T2DM的病理生理机制与不同部位脂肪组织分泌的脂肪因子差异性密切相关。内脏脂肪组织较皮下脂肪组织高分泌Adipsin,其作为脂肪细胞分泌的一类细胞信号蛋白,参与补体旁路途径(the alternative complement pathway,AP)的限速步骤,在缺血再灌注和败血症等病理过程中发挥重要作用。然而,关于Adipsin在T2DM中的作用及潜在机制的研究尚待深入,正如肠促胰素提供来自胃肠系统的提示一样,Adipsin可能沿着脂肪向胰岛轴传递信号。本综述将系统地概述脂肪因子Adipsin从临床到动物实验对血糖调控的影响和潜在机制,旨在为脂代谢紊乱所致血糖升高的发病机制提供新的解释,并为T2DM的诊断和治疗提供新的思路。

The prevalence of type 2 diabetes mellitus(T2DM)on a global scale has had a huge impact on public health.The pathophysiological mechanism of T2DM is closely related to the adipokines secreted by different regional fat depot.Visceral adipose tissue secretes more adipsin than subcutaneous adipose tissue.Adipsin,a cell signaling protein secreted by adipocytes,participates in the limited activation speed of the alternative complement pathway(AP)and plays an important role in pathological processes such as ischemia-reperfusion and sepsis.However,studies on the role and underlying mechanisms of adipsin in T2DM are not yet clear.Just as incretin provides cues from the gastrointestinal system,adipsin may signal along the fat-to-islet axis.This review systematically summarizes the effect of adipsin on blood sugar regulation and the potential mechanisms from clinical practice to animal experiments,aiming to provide a new explanation for the pathogenesis of hyperglycemia caused by lipid metabolism disorders,and new ideas for the diagnosis and treatment of T2DM.