参芪补肺法联合西药在慢性阻塞性肺疾病治疗中的应用效果

Effect of Shenqi Bufei method combined with western medicine in the treatment of chronic obstructive pulmonary disease

目的探讨参芪补肺法联合西药在慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)治疗中的应用效果。方法选择2018年9月至2020年8月本院接诊的110例轻中度稳定期COPD肺气虚证患者,将其随机分为对照组及干预组,每组55例。对照组应用常规西药治疗,干预组在对照组基础上采用参芪补肺法治疗,疗程3个月。比较两组疗效、中医证候积分、肺功能指标[第1秒用力呼气容积(forced expiratory volume in the first second,FEV1)、用力肺活量(forced vital capacity,FVC)]、血氧指标[动脉血二氧化碳分压(arterial partial pressure of carbon dioxide,PaCO_(2))、动脉血氧分压(arterial partial pressure of oxygen,PaO_(2))]、6 min步行距离(6 min walking distance,6MWD)及不良反应发生率。结果干预组治疗总有效率明显高于对照组(P<0.05)。治疗后,两组FEV1、FVC、PaO_(2)及6MWD均增高,且干预组均高于对照组(P<0.05)。治疗后,两组中医证候积分及PaCO_(2)均降低,且干预组均低于对照组(P<0.05)。干预组不良反应总发生率明显低于对照组(P<0.05)。结论对轻中度稳定期COPD肺气虚证患者予以参芪补肺法联合西药治疗,疗效较为理想,可明显降低患者中医证候积分,显著改善肺功能及血氧指标,有效增强运动耐量,且用药安全性高。

Objective To investigate the effect of Shenqi Bufei method combined with western medicine in the treatment of chronic obstructive pulmonary disease(COPD).Methods A total of 110 patients with stable lung qi deficiency syndrome of mild to moderate COPD admitted to our hospital from September 2018 to August 2020 were selected,and randomly divided into control group and intervention group with 55 pattents in each group.The control group were treated with conventional western medicine,and the intervention group were treated with Shenqi Bufei method on the basis of the control group.The course of the treatment was 3 months.The curative effect,traditional Chinese medicine syndrome score,pulmonary function index[forced expiratory volume in the first second(FEV1),forced vital capacity(FVC)],blood oxygen index[arterial partial pressure of carbon dioxide(PaCO_(2)),arterial partial pressure of oxygen(PaO_(2))],6-minute walking distance(6MWD)and incidence of adverse reactions were compared between the two groups.Results The total effective rate of intervention group was significantly higher than that of control group(P<0.05).After treatment,FEV1,FVC,PaO_(2)and 6MWD in the two groups were increased,and the intervention group was significantly higher than that of control group(P<0.05).After treatment,the traditional Chinese medicine syndrome score and PaCO_(2)of the two groups were decreased,and the intervention group was significantly lower than that of control group(P<0.05).The total incidence of adverse reactions in the intervention group was significantly lower than that of control group(P<0.05).Conclusion For mild to moderate COPD patients with lung qi deficiency syndrome,Shenqi Bufei method combined with western medicine has an ideal effect,which can significantly reduce the traditional Chinese medicine syndrome score,significantly improve lung function and blood oxygen index,effectively enhance exercise tolerance,and has high drug safety.