摘要
Fibulin-1是存在于细胞外基质(extracellular matrix,ECM)中的一种糖蛋白,与细胞活动和ECM功能的调控密切相关。Fibulin-1参与肝纤维化及肝癌的发生发展,不仅可通过结合弹性蛋白和蛋白多糖、介导肝脏损伤等触发肝纤维化并参与肝纤维化过程中的组织重塑,评估肝纤维化的严重程度,还可通过抑制肿瘤细胞凋亡、调节肿瘤相关细胞间质来影响不同类型肝癌的发生及进展。此外,Fibulin-1的不同亚型在肿瘤发生发展过程中发挥双重作用,在不同类型的肿瘤中具有不同的表达特点。
Fibulin-1 is an extracellular matrix(ECM)glycoprotein,which is associated with the regulation of cell behavior and ECM function.Fibulin-1 also acts as mediator of progression of liver fibrosis and liver cancer.It can not only affect the remolding of ECM by binding to ECM protein in liver fibrosis and evaluate fibrosis stage,but also regulate liver cancer through suppressing cell apotosis and changing tumor-related ECM.In addition,different varients of Fibulin-1 play a dual role in tumor development and have different expression characteristics in different types of tumors.
作者
张警予
赵文姗
谢雯
Zhang Jingyu;Zhao Wenshan;Xie Wen(Department of Hepatology Division 1,Beijing Ditan Hospital,Capital Medical University,Beijing 100015,China)
出处
《中国肝脏病杂志（电子版）》
CAS
2022年第4期15-19,共5页
Chinese Journal of Liver Diseases：Electronic Version
基金
国家自然科学基金(81900547)
北京市医院管理中心创新梦工场经费资助(202138)。
