胃癌组织TRAF4和RSK4蛋白表达与腹腔镜根治术后复发的关系

Correlation of TRAF4 and RSK4 Protein Expression Levels in Gastric Cancer Tissues with Recurrence After Laparoscopic Radical Resection

目的探讨胃癌组织TRAF4、RSK4蛋白表达与腹腔镜胃癌根治术后复发的关系。方法将176例患者分为复发组和未复发组,对比癌组织与癌旁组织、复发组与未复发组胃癌组织中TRAF4和RSK4蛋白表达。分析复发的影响因素及二者预测复发的效能。结果胃癌组织中TRAF4蛋白阳性表达率高于癌旁组织(P<0.05),且复发组高于未复发组(P<0.05);胃癌组织RSK4蛋白阳性表达率低于癌旁组织(P<0.05),且复发组低于未复发组(P<0.05);最大肿瘤直径>5 cm、低分化、TNMⅢ期、浸润深度T3~T4、淋巴结转移、术后未辅助化疗、TRAF4和RSK4蛋白阳性表达、规律饮食均是术后复发的影响因素(均P<0.05);胃癌组织TRAF4、RSK4蛋白联合预测复发的准确度为83.52%。结论胃癌组织TRAF4蛋白高表达、RSK4蛋白低表达,且均与复发有关。

Objective To investigate the relationships between the expression levels of tumor necrosis factor receptor associated factor 4(TRAF4)and ribosomal S6 protein kinase 4(RSK4)protein in gastric cancer tissues and the recurrence after laparoscopic radical gastrectomy.Methods In total,176 patients were divided into the recurrence and non-recurrence group,and the expression levels of TRAF4 and RSK4 protein in cancer and adjacent tissues and in gastric cancer tissues in the recurrence and non-recurrence group were compared.The influencing factor of recurrence and the efficacy of TRAF4 and RSK4 protein expression in predicting recurrence were analyzed.Results The positive expression rate of TRAF4 protein in gastric cancer tissues was higher than that in adjacent tissues(P<0.05)and that in the recurrence group was higher than that in the non-recurrence group(P<0.05).The positive expression rate of RSK4 protein in gastric cancer tissues was lower than that in adjacent tissues(P<0.05)and that in the recurrence group was lower than that in non-recurrence group(P<0.05).The largest tumor diameter 5 cm,poor differentiation,TNMⅢstage,depth of invasion T3-T4,lymph node metastasis,absence of adjuvant chemotherapy after operation,positive expression of TRAF4 and RSK4 protein,and regular diet w influenced the post-operative recurrence(all P<0.05).The accuracy of TRAF4 and RSK4 protein in gastric cancer tissues in combined predicting the recurrence was 83.52%.Conclusion The expression of TRAF4 protein is high,and the RSK4 protein is low in gastric cancer tissue,which are related to recurrence.