糖尿病患者基因多态性与乳腺癌发病及预后的相关性

Correlation Between Gene Polymorphism and Breast Cancer Incidence and Prognosis for Patients with Diabetes

目的分析2型糖尿病(T2DM)患者脂肪质量和肥胖相关(FTO)基因、IL-6和HSP-60基因多态性对乳腺癌(BCa)发病率和预后的影响。方法试验组纳入BCa患者1551例,对照组纳入同年龄层健康体检女性1605例。通过基线资料调研问卷收集3156例试验参与者临床资料,通过血样检测参与者FTO、IL-6和HSP-60单核苷酸多态性(SNP)位点基因型。评价三种SNP对T2DM患者BCa发病风险的预测价值。通过随访获取1168例BCa患者OS,评价三种SNP和T2DM对BCa患者OS的影响。结果三个位点分别为FTO rs3751812、IL-6 rs1800796和HSP-60 rs2605039。任一SNP基因型为野生纯合子的T2DM女性BCa发病风险显著高于非T2DM女性(FTO:χ^(2)=3.530,P=0.013;IL-6:χ^(2)=6.288,P=0.029;HSP-60:χ^(2)=4.926,P=0.005)。三种野生纯合子基因型均是影响BCa发病率的独立风险因素(均P<0.05)。HSP-60 rs2605039暴露组(GT+TT)基因型患者具有更好的OS(P=0.031)。结论FTO、IL-6和HSP-60基因多态性对T2DM患者BCa发病风险的预测具有一定意义,HSP-60 rs2605039 GT+TT基因型BCa患者具有更好的OS。

Objective To analyze the effects of fat mass and obesity-associated(FTO)gene,IL-6,and HSP-60 gene polymorphism on the incidence rate and prognosis of breast cancer(BCa)for patients with type 2 diabetes mellitus(T2DM).Methods A total of 1551 patients with BCa were included in the experimental group and 1605 women of the same age who participated in physical examination were included in the control group.The clinical data of the 3156 participants were collected through the baseline data questionnaire,and the genotypes of FTO,IL-6,and HSP-60 single-nucleotide polymorphism(SNP)were determined through blood sample detection.The predictive value of the three SNPs for the incidence risk of BCa for T2DM patients was evaluated.The OS of 1168 patients with BCa was obtained through follow-up,and the effects of the three SNPs and T2DM on OS of BCa patients were evaluated.Results The three loci were FTO rs3751812,IL-6 rs1800796,and HSP-60 rs2605039.The BCa incidence rate for T2DM women with wild homozygous SNP genotype was significantly higher than that for non-T2DM women(FTO:χ^(2)=3.530,P=0.013;IL-6:χ^(2)=6.288,P=0.029;HSP-60:χ^(2)=4.926,P=0.005).The three wild homozygous genotypes were independent risk factors that influenced the incidence rate of BCa(all P<0.05).Patients with HSP-60 rs2605039(GT+TT)genotype had better OS(P=0.031).Conclusion FTO,IL-6,and HSP-60 gene polymorphisms have certain value in BCa prediction for T2DM patients.Patients with BCa and HSP-60 rs2605039 GT+TT genotype have high OS.