巴豆酰化修饰在恶性肿瘤中的研究进展

Research Progress on Crotonylation in Malignant Tumor

作为一种新发现的翻译后修饰,巴豆酰化修饰在组蛋白和非组蛋白中均被证实大量存在,并参与了多种疾病和生物学过程的调控。随着高分辨率质谱检测技术的发展,越来越多的内源性巴豆酰化修饰被检测并鉴定。另一方面,巴豆酰化修饰调控酶的发现,为进一步研究巴豆酰化修饰的机制提供了有力支持。本文对巴豆酰化修饰的生物学功能及其在真核生物体内的修饰调控机制进行概述,并介绍近年来巴豆酰化修饰在恶性肿瘤研究中的进展。

As a newly discovered posttranslational modification(PTM),crotonylation has been identified in histone and nonhistone proteins and has important roles in the regulation of various diseases and biological processes.With the development of high-resolution mass spectrometry approaches,an increasing number of endogenous crotonylation has been detected and identified.The discovery of crotonylation regulatory enzymes paved the way for the study of crotonylation mechanism.In this review,we summarize the biological functions and regulatory mechanism of crotonylation in eukaryotes and introduce the recent progress on crotonylation in malignant tumor.