microRNA在不同类型骨骼肌萎缩中的研究进展

Research progress of microRNA in different types of skeletal muscle atrophy

骨骼肌萎缩是指骨骼肌质量的减少及肌肉功能的降低,去神经、衰老及慢性阻塞性肺疾病、癌症等各种疾病均可诱发骨骼肌萎缩,从而导致患者生活质量下降,死亡风险增加。然而,肌肉萎缩的潜在机制尚不完全清楚。微RNA(miRNA)是一类由内源性基因编码的非编码单链RNA分子,参与多种生理和病理过程,包括细胞增殖、分化、凋亡、自噬及肿瘤发生,甚至表观遗传。近年来关于miRNA在骨骼肌萎缩中的研究越来越多,miRNA有望成为骨骼肌萎缩诊断与治疗的新分子靶标。本文就miRNA在不同类型骨骼肌萎缩中的作用研究进展进行综述。

Skeletal muscle atrophy refers to the decrease of skeletal muscle quality and muscle function.Denervation,aging,chronic obstructive pulmonary disease,cancer,and other diseases can induce skeletal muscle atrophy,resulting in a decline in the quality of life of patients and an increased risk of death.However,the underlying mechanism of muscle atrophy is not fully understood.microRNA(miRNA)is a class of non-coding single-stranded RNA molecules encoded by endogenous genes,which are involved in a variety of physiological and pathological processes,including cell proliferation,differentiation,apoptosis,autophagy,tumorigenesis,and even epigenetics.In recent years,there are more and more studies on miRNA in skeletal muscle atrophy,and miRNA is expected to become a new molecular target for the diagnosis and treatment of skeletal muscle atrophy.This article reviews the research progress on the role of miRNA in different types of skeletal muscle atrophy.