国家专利数据库的中药复方治疗胰腺癌用药规律分析

Analysis of medication rule of traditional Chinese medicine compound prescription in treating pancreatic cancer based on national patent database

目的基于数据挖掘探讨国家专利数据库的中药复方治疗胰腺癌的用药规律。方法通过中国专利公布公告网站检索建库至2022年5月治疗胰腺癌的中药复方专利,使用Excel软件建立复方数据库,运用古今医案云平台、IBM SPSS Modeler及IBM SPSS Statistics软件将规范后的数据进行用药规律分析。结果共纳入治疗胰腺癌的中药复方专利55项,包含中药426味。药性以寒、温为主;药味以苦、甘、辛为主;归经以肝、脾、肺为主;高频单味药有白花蛇舌草、甘草、白术、延胡索、半枝莲、当归、薏苡仁、柴胡等。常用药对是白术-甘草、白花蛇舌草-半枝莲等;关联分析获得药物组合27个;高频药物聚类分析获得3个核心药物组合。结论中药复方专利治疗胰腺癌有规律可循,组方寒温并用,调和肝脾,以扶正固本,解毒抑瘤为基本治法。

Objective To analyze the medication rule of traditional Chinese medicine compound prescription of national patent database in treating pancreatic cancer based on data mining.Methods The patent of traditional Chinese medicine compound prescription for treating pancreatic cancer from inception to May 2022 were searched by China Patent Announcement website.The prescription database was established with Excel software.The ancient and modern medical case cloud platform,IBM SPSS Modeler,and IBM SPSS Statistics software were used to analyze the medication rules of normalized data.Results A total of 55 traditional Chinese medicine compound prescriptions patents for the treatment of pancreatic cancer were included,including 426 Chinese herbs.Their properties were mainly cold and warm;the tastes were mainly bitter,sweet,and pungent;drugs were mainly belong to liver,spleen,and lung channel tropism.High-frequency single traditional Chinese medicines include Herba Hedyotis,Radix Glycyrrhizae,Rhizoma Atractylodis Macrocephalae,Rhizoma Corydalis,Herba Scutellariae Barbatae,Radix Angelicae Sinensis,Semen Coicis,and Radix Bupleuri,etc.High-frequency drug pairs included“Rhizoma Atractylodis Macrocephalae-Radix Glycyrrhizae”and“Herba Hedyotis-Herba Scutellariae Barbatae”,etc.The association rule analysis obtained 27 drug groups.Three core drug groups were obtained by cluster analysis of high-frequency drugs.Conclusion The treatment of pancreatic cancer with traditional Chinese medicine compound prescription has an obvious rule.In the treatment of pancreatic cancer,the formula can be combined with cold and warm drugs,and harmonize the liver and spleen.The basic treatment is strengthening and consolidating body resistance,removing toxicity and inhibiting tumor growth.