基于中医文献探析特应性皮炎的内服中草药规律

Exploration on the rule of taking herbal medicine internally in atopic dermatitis based on Chinese medicine literature

目的分析治疗特应性皮炎的内服中草药规律。方法筛选中华医典、中国知网、万方数据库及维普网1990年1月至2022年3月涉及特应性皮炎内治的文献,采用频次分析、聚类分析、关联规则及构建复杂网络等方法,统计中药的频次、四气、五味、归经、功效、关联药对及核心中药,分析治疗特应性皮炎的用药规律。结果共收录文献237篇,处方151首,中药211味。治疗特应性皮炎时多使用甘草、茯苓、当归、白术等,用药药性以寒、温为主,药味多偏甘、苦、辛,归经以脾、肺、肝、胃为主,中药功效以清热、补气、利水渗湿、疏风为主。出现次数最多的药物组合为白术-茯苓,通过复杂网络分析得到了治疗特应性皮炎的核心中药。结论中医治疗特应性皮炎以疏风清热、健脾化湿、养血润燥为主,可为特应性皮炎的临床治疗提供理论参考。

Objective To analyze the rule of taking herbal medicine internally in treating atopic dermatitis.Methods Literatures related to internal treatment of atopic dermatitis were selected from Chinese Medical Code,China National Knowledge Network,Wanfang Data,and VIP from January 1990 to March 2022.The frequency analysis,cluster analysis,association rules,and complex network construction methods were used to count the frequency,four qi,five flavor,meridian normalization,efficacy,associated drug pairs,and core Chinese medicines,and the medication rule of atopic dermatitis was analyzed.Results A total of 237 literatures,151 prescriptions,and 211 traditional Chinese medicines were included.In the treatment of atopic dermatitis,licorice,poria,Radix angica,atractylodes,and so on were used.The drug properties were mainly cold and warm,and the drug tastes were mostly sweet,bitter,and pungent.The main function of returning to the channel were spleen,lung,liver,and stomach,and the main effect of traditional Chinese medicine was clearing heat,benefiting qi,promoting water and dampness,dispelling wind.The most frequent drug combination was atractylodes,poria cocos.Through complex network analysis,the core traditional Chinese medicine for atopic dermatitis was obtained.Conclusion Traditional Chinese medicine treatment of atopic dermatitis mainly focuses on dispelling wind and clearing heat,strengthening spleen and dampness,nourishing blood and moistening dryness,which can provide theoretical reference for clinical treatment of atopic dermatitis.