摘要
急性肾损伤是以肾功能急性丧失为特征的临床综合征,发病机制复杂。姜黄素可通过稳定线粒体功能、减轻肾缺血再灌注损伤、抗炎、抗氧化、调控巨噬细胞功能、抗肾间质纤维化、抗凝血障碍等多种途径发挥防治急性肾损伤的作用。总结了姜黄素防治急性肾损伤的作用及其机制,希望为姜黄素的临床使用提供参考。
Acute renal injury is a clinical syndrome characterized by acute loss of renal function, and its pathogenesis is complex.Curcumin can play a role in prevention and treatment of acute renal injury by stabilizing mitochondrial function, alleviating renal ischemia reperfusion injury, anti-inflammation, anti-oxidation, regulating macrophage function, anti-renal interstitial fibrosis,anticoagulation disorders, and other ways. This article summarized the role and mechanism of curcumin in prevention and treatment of acute renal injury, hoping to provide a reference for the clinical use of curcumin.
作者
刘宵琴
刘力沛
杨小冬
LIU Xiao-qin;LIU Li-pei;YANG Xiao-dong(Internal Medicine Department of Traditional Chinese Medicine,Shijiazhuang Hetaiheng Hospital,Shijiazhuang 050000,China)
出处
《现代药物与临床》
CAS
2023年第1期239-244,共6页
Drugs & Clinic
基金
石家庄市科学技术研究与发展计划项目(191460813)。
关键词
姜黄素
急性肾损伤
线粒体
肾缺血再灌注损伤
抗炎
抗氧化
巨噬细胞功能
肾间质纤维化
凝血障碍
curcumin
acute kidney injury
mitochondria
renal ischemia-reperfusion injury
anti-inflammatory
anti-oxidation
macrophage function
renal interstitial fibrosis
blood clotting disorder
