宫颈癌患者血清双皮质素样激酶1、黏蛋白-1、血管生成素-2的表达及临床意义

Expression and clinical significance of serum bisocorticoid kinase 1,mucin-1 and angiopoietin-2 in patients with cervical cancer

目的探讨宫颈癌患者血清双皮质素样激酶1(DCLK1)、黏蛋白-1(MUC-1)、血管生成素-2(Ang-2)的表达及临床意义。方法选择该院2018年2月至2019年2月收治的102例宫颈癌患者为研究对象。分析血清DCLK1、MUC-1及Ang-2表达水平与患者临床病理参数的关系。以血清DCLK1、MUC-1及Ang-2表达水平中位数为界(高于中位数为高表达,低于中位数为低表达),分析上述3项指标高表达和低表达患者的3年总生存率。分析宫颈癌患者预后的影响因素。分析血清DCLK1、MUC-1及Ang-2单独及联合检测预测宫颈癌患者预后的效能。结果国际妇产科联盟(FIGO)分期Ⅲ~Ⅳ期及有淋巴结转移的宫颈癌患者血清DCLK1、MUC-1表达水平分别高于FIGO分期Ⅰ~Ⅱ期及无淋巴结转移的患者,FIGO分期Ⅲ~Ⅳ期的宫颈癌患者血清Ang-2表达水平高于FIGO分期Ⅰ~Ⅱ期的患者,差异均有统计学意义(P<0.05)。血清DCLK1、MUC-1及Ang-2高表达患者3年总生存率均明显低于对应的低表达患者,差异有统计学意义(P<0.05)。Cox回归分析结果显示,血清DCLK1、MUC-1、Ang-2表达水平及FIGO分期、淋巴结转移情况均是宫颈癌患者预后的影响因素(P<0.05)。受试者工作特征曲线分析结果显示,血清DCLK1、MUC-1、Ang-2单独及联合检测预测宫颈癌患者预后的曲线下面积(AUC)分别为0.687、0.728、0.694、0.836,联合检测的预测效能最高,其AUC高于各指标单独检测(P<0.05)。结论血清DCLK1、MUC-1、Ang-2表达水平与宫颈癌进展及预后有关,检测上述3项指标可为患者的病情评估及预后预测提供指导依据。

Objective To investigate the expression and clinical significance of serum bisocorticoid kinase 1(DCLK1),mucin-1(MUC-1)and angiopoietin-2(Ang-2)in patients with cervical cancer.Methods A total of 102 patients with cervical cancer admitted to the hospital from February 2018 to February 2019 were selected as the study subjects.The relationship between the expression levels of serum DCLK1,MUC-1 and Ang-2 and the clinicopathological parameters of patients was analyzed.The median expression levels of serum DCLK1,MUC-1 and Ang-2 were used as the boundary(higher than the median was high expression,lower than the median was low expression),the 3-year overall survival rate of patients with high and low expression of the above 3 indicators was analyzed.The prognostic factors of patients with cervical cancer were analyzed.The efficacy of serum DCLK1,MUC-1 and Ang-2 individual and combined detection in predicting the prognosis of patients with cervical cancer was analyzed.Results The expression levels of serum DCLK1 and MUC-1 in cervical cancer patients with FIGO stageⅢto stageⅣand lymph node metastasis were higher than those in patients with FIGO stageⅠto stageⅡand without lymph node metastasis respectively,the expression level of serum Ang-2 in cervical cancer patients with FIGO stageⅢto stageⅣwas higher than that in patients with FIGO stageⅠto stageⅡ,and the differences were statistically significant(P<0.05).The 3-year overall survival rate of patients with high expression of DCLK1,MUC-1 and Ang-2 was significantly lower than that of patients with low expression,and the differences were statistically significant(P<0.05).Cox regression analysis showed that serum DCLK1,MUC-1,Ang-2 expression levels,FIGO stage and lymph node metastasis situation were prognostic factors of cervical cancer patients(P<0.05).The analysis results of the receiver operating characteristic curve showed that the area under the curve(AUC)for predicting the prognosis of patients with cervical cancer by serum DCLK1,MUC-1 and Ang-2 individual and combined detection were 0.687,0.728,0.694 and 0.836 respectively,combined detection has the highest predictive efficiency,and its AUC was higher than that of individual detection(P<0.05).Conclusion The expression levels of serum DCLK1,MUC-1 and Ang-2 are related to the progression and prognosis of cervical cancer.The detection of these 3 indicators could provide guidance for the evaluation of patients′condition and prognosis.