炎症反应介导认知功能障碍与麻醉策略的研究进展

Advances in Inflammatory Response-mediated Cognitive Dysfunction and Anesthesia Strategies

认知功能障碍(cognitive impairment,CI)是指各种原因引起的程度各异的中枢神经系统损害,是老年人常见的临床症状,其危险因素及诱发原因非常复杂,具体病理生理机制尚不明确。近年来,逐渐增多的证据表明CI与炎症反应密切相关。围术期采用不同的麻醉策略可影响炎症反应的发生、发展,本研究针对炎症反应介导认知功能障碍与麻醉策略间的关系进行综述,为临床和基础更好的开展该领域研究提供参考。

Cognitive impairment(CI) is a common clinical condition in the elderly with varying degrees of central nervous system damage caused by various causes, and its risk factors and precipitating causes are very complex, and the specific pathophysiological mechanisms are still unclear. In recent years, there is growing evidence that CI is closely associated with inflammatory responses. Different anesthesia strategies during perioperative period can affect the occurrence and development of inflammatory response. The use of different anesthetic strategies during the perioperative period can influence the onset and development of the inflammatory response. A review of the relationship between inflammatory response-mediated cognitive dysfunction and anesthesia strategies was conducted to provide a reference for better clinical and basic research in this area.