免疫学检验联合检测对诊断类风湿关节炎的效果

Effect of combined immunoassay examination in the diagnosis of rheumatoid arthritis

目的 探讨分析对类风湿关节炎(RA)患者采用免疫学检验联合检测进行诊断的作用。方法 本次研究对象均选自天津市宝坻区人民医院 2019 年 12 月—2020 年 12 月收治的 RA 患者 93 例,并设定为研究组,另选取同期在该院接受体检的健康受检者 93 例作为对照组,对两组均进行免疫学检验联合检测,比较对两组的类风湿因子阳性率、抗环瓜氨酸肽抗体阳性率以及各项免疫学指标。结果 研究组类风湿因子阳性率为 86.0%,高于对照组的 2.2%,差异有统计学意义(χ2=132.695,P<0.05)。研究组抗环瓜氨酸肽抗体阳性率为 83.9%,高于对照组的 1.1%,差异有统计学意义(χ2=130.462,P<0.05)。研究组免疫球蛋白水平高于对照组,补体 C3、补体 C4 水平低于对照组,差异均有统计学意义(P<0.05)。结论根据本次研究的结果可以确认,对 RA 患者采用免疫学检验联合检测进行诊断有着十分确切的作用,不仅可以很好地为患者确诊,还能够获取更为全面的病情资料,这样就可以为后续治疗提供数据参考,值得在临床上广泛应用。

Objective To explore and analyze the role of combined immunoassay examination in the diagnosis of patients with rheumatoid arthritis. Methods A total of 93 patients with rheumatoid arthritis treated in Tianjin Baodi District People’s Hospital from December 2019 to December 2020 were selected as study group,and 93 healthy subjects who underwent physical examination in this hospital in the same period were selected as control group. The two groups were tested by combined immunoassay examination,and the positive rates of rheumatoid factor, positive rate of anti cyclic citrullinated peptide antibody and various immunological indexes in the two groups were compared. Results The positive rate of rheumatoid factor in the study group was 8 6 . 0%,which was higher than 2. 2% in the control group,and the difference was statistically significant(χ~2=1 32. 6 9 5,P< 0. 05). The positive rate of anti cyclic citrullinated peptide antibody in the study group was 8 3. 9 % ,which was higher than 1 . 1 % in the control group,and the difference was statistically significant (χ~2=1 30. 4 6 2,P < 0. 05). The immunoglobulin was higher than that in the control group,the complement C3 and complement C4 in the study group were lower than those in the control group,and the differences were statistically significant (P<0.05). Conclusion According to the results of this study,it could be confirmed that the combined immunoassay examination played a very definite role in the diagnosis of patients with rheumatoid arthritis. It could not only diagnose patients well,but also obtain more comprehensive condition data,which could provide data reference for follow -up treatment and was worthy of wide application in clinic.