丁二磺酸腺苷蛋氨酸联合熊去氧胆酸在药物性肝炎患者中的治疗效果评估

Evaluation of the Therapeutic Effect of Adenosylmethionine Butanedisulfonate Combined with Ursodeoxycholic Acid in Patients with Drug-induced Hepatitis

目的 探析药物性肝炎患者采取丁二磺酸腺苷蛋氨酸+熊去氧胆酸治疗的临床效果。方法 随机选取2017年1月—2021年11月三明市第二医院感染科收治的80例药物性肝炎患者,按照随机法分为对照组40例(还原型谷胱甘肽治疗)、研究组40例(丁二磺酸腺苷蛋氨酸+熊去氧胆酸治疗),对比两组治疗效果。结果研究组临床症状指标均低于对照组,差异有统计学意义(P<0.05);研究组肝功能指标均低于对照组,差异有统计学意义(P<0.05);研究组炎性指标均低于对照组,差异有统计学意义(P<0.05);观察组治疗效果为97.50%高于对照组的75.00%,差异有统计学意义(χ^(2)=8.538,P<0.05)。结论 药物性肝炎患者采用丁二磺酸腺苷蛋氨酸+熊去氧胆酸治疗,具有较高临床价值。

Objective To analyze the clinical effect of ademetionine butanedisulfonate+ursodeoxycholic acid in patients with drug-induced hepatitis. Methods A total of 80 patients with drug-induced hepatitis admitted to the Department of Infection, Sanming Second Hospital from January 2017 to November 2021 were randomly selected and randomly divided into control group(40 cases treated with reduced glutathione) and study group(40 cases treated with adenosyl methionine succinate + ursodeoxycholic acid). The treatment effect of the two groups were compared. Results The clinical symptom indicators of the study group were lower than those of the control group, and the difference was statistically significant(P<0.05). The liver function index of the study group were lower than those of the control group, and the difference was statistically significant(P<0.05). The inflammatory index of the study group were lower than those of the control group, and the difference was statistically significant(P<0.05). The treatment effect of observation group was 97.50% higher than that of control group 75.00%, and the difference was statistically significant(χ^(2)=8.538, P<0.05).Conclusion The treatment of drug-induced hepatitis patients with adenosylmethionine butanedisulfonate + ursodeoxycholic acid has high clinical value.