结直肠息肉患者Hp感染临床特点及其与G-17、 sIL-2R和COX-2的关系

Clinical characteristics of Hp infection in patients with colorectal polyps and its association with G-17, SIL-2R and COX-2

目的 探究结直肠息肉患者幽门螺杆菌(Hp)感染临床特点及血浆胃泌素-17(G-17)、可溶性白细胞介素2受体(sIL-2R)的表达水平及结直肠组织环氧合酶-2(COX-2)阳性率。方法 选取2019年3月-2021年7月武汉市第八医院收治的89例结直肠息肉患者为研究对象,依据患者Hp感染情况,分为Hp阳性组58例和Hp阴性组31例,分析两组患者临床特点,比较两组患者血浆G-17、sIL-2R水平及结直肠组织COX-2阳性率,受试者工作特征(ROC)曲线分析G-17、sIL-2R、COX-2对结直肠息肉患者Hp感染的诊断价值。结果 Hp阳性组患者多发息肉检出率高于Hp阴性组,其中炎性息肉、增生性息肉、腺瘤性息肉患者Ⅰ型Hp检出率呈升高趋势(P<0.05);Hp阳性组G-17、sIL-2R水平及COX-2阳性率高于Hp阴性组(P<0.05);G-17、sIL-2R水平及COX-2表达联合检测诊断结直肠息肉患者Hp感染的AUC为0.854,敏感度为77.59%,特异度为83.87%。结论 不同病理类型结直肠息肉患者的Hp感染类型不同,血浆G-17、sIL-2R水平及COX-2表达与Hp感染相关,并对结直肠息肉患者Hp感染具有诊断价值。

OBJECTIVE To explore the clinical characteristics of Helicobacter pylori(Hp) infection, expression levels of plasma gastrin-17(G-17) and soluble interleukin-2 receptor(sIL-2R), and positive rate of cyclooxygenase-2(COX-2) in colorectal tissues of patients with colorectal polyps. METHODS A total of 89 patients with colorectal polyps who were treated in Wuhan Eighth Hospital from Mar 2019 to Jul 2021 were recruited as the study subjects and divided into the Hp-positive group with 58 cases and the Hp-negative group with 31 cases according to the status of Hp infection. The clinical characteristics were observed, the expression levels of plasma G-17, sIL-2R and the positive rate of COX-2 in colorectal tissue were compared between the two groups of patients, and the values of G-17, sIL-2R and COX-2 in diagnosis of Hp infection were analyzed by means of receiver operating characteristic(ROC) curves. RESULTS The detection rate of multiple polyps of the Hp-positive group was higher than that of the Hp-negative group, the positive rate of typeⅠ Hp showed upward trend among the patients with inflammatory polyps, hyperplastic polyps and adenomatous polyps(P<0.05). The expression levels of G-17, Sil-2R and positive rate of COX-2 were higher in the Hp-positive group than in the Hp-negative group(P<0.05). The area under curve(AUC) of the joint detection of G-17, sIL-2R and COX-2 was 0.854 in diagnosis of Hp infection, with the sensitivity 77.59%, the specificity 83.87%. CONCLUSION The patients with different pathological patterns of colorectal polyps vary in the type of Hp infection, and the Hp infection is associated with the expression levels of plasma G-17, sIL-2R and COX-2, which have value in diagnosis of Hp infection in the patients with colorectal polyps.