摘要
Colorectal cancer(CRC)is the second deadliest cancer and the third-most common malignancy in the world.Surgery,chemotherapy,and targeted therapy have been widely used to treat CRC,but some patients still develop resistance to these treatments.Ferroptosis is a novel non-apoptotic form of cell death.It is an iron-dependent non-apoptotic cell death characterized by the accumulation of lipid reactive oxygen species and has been suggested to play a role in reversing resistance to anticancer drugs.This review summarizes recent advances in the prognostic role of ferroptosis in CRC and the mechanism of action in CRC.
基金
Supported by Medical Health Science and Technology Project of Zhejiang Province,No.2021PY083
Program of Taizhou Science and Technology Grant,No.22ywb09 and No.1901ky18
Key Technology Research and Development Program of Zhejiang Province,No.2019C03040
Major Research Program of Taizhou Enze Medical Center Grant,No.19EZZDA2.
