Liver injury in COVID-19:Holds ferritinophagy-mediated ferroptosis accountable

Even in patients without a history of liver disease,liver injury caused by coronavirus disease 2019(COVID-19)is gradually becoming more common.However,the precise pathophysiological mechanisms behind COVID-19’s liver pathogenicity are still not fully understood.We hypothesize that inflammation may become worse by cytokine storms caused by the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection.Elevated ferritin levels can initiate ferritinophagy mediated by nuclear receptor coactivator 4(NCOA4),which leads to iron elevation,and ferroptosis.In COVID-19 patients,ferroptosis can be restricted to reduce disease severity and liver damage by targeting NCOA4-mediated ferritinophagy.To confirm the role of ferritinophagy-mediated ferroptosis in SARS-CoV-2 infection,further research is required.