上海某院体检女性血清25羟维生素D与甲状腺自身抗体及甲状腺结节间的关系

Association between serum 25-hydroxyvitamin D and thyroid autoantibodies and thyroid nodules in women for health examination in Shanghai

【目的】研究上海某疗养院女性体检人群血清25羟维生素D[25(OH)D]水平与甲状腺自身抗体及甲状腺结节间的关系。【方法】回顾性分析2108例来院体检女性的资料,根据血清25(OH)D值分为充足组[25(OH)D≥30μg·L^(-1)]、不足组[20μg·L^(-1)≤25(OH)D<30μg·L^(-1)]、缺乏组[10μg·L^(-1)≤25(OH)D<20μg·L^(-1)]及严重缺乏组(<10μg·L^(-1))。比较各组血清25(OH)D水平与甲状腺自身抗体及甲状腺结节间的关系。【结果】2108例体检女性的25(OH)D缺乏率为69.31%;维生素D严重缺乏组与充足组间的碱性磷酸酶(ALP)、低密度脂蛋白(LDL)、抗甲状腺球蛋白抗体(TGAB)、抗甲状腺过氧化物酶抗体(TPOAB)水平差异有统计学意义(P<0.05);甲状腺结节的患病率、TGAB阳性率、TGAB和(或)TPOAB阳性率在4组间差异有统计学意义(χ^(2)趋势分别为81.299、16.194、11.202,均P<0.05)。logistic回归分析显示,血清25(OH)D水平与年龄、甲状腺结节患病率、TGAB阳性率、TGAB和(或)TPOAB阳性率相关,且随着缺乏程度的加重,风险逐渐增加。【结论】该疗养院体检女性维生素D缺乏率较高,血清25(OH)D不足或缺乏,与年龄、甲状腺自身抗体阳性及结节的发生相关。

[Objective]To determine the level of serum 25-hydroxyvitamin D(25(OH)D)and its association with thyroid autoantibodies and thyroid nodules in adult women for health examination in Shanghai.[Methods]We recruited a total of 2108 healthy women for examination in the hospital.According to the serum 25-hydroxyvitamin D,the women were classified into four groups:25(OH)D≥30μg·L^(-1)as sufficient group,20μg·L^(-1)≤25(OH)D<30μg·L^(-1)as insufficient group,10μg·L^(-1)≤25(OH)D<20μg·L^(-1)as the deficiency group,and<10μg·L^(-1)as severe deficiency group.The association was determined between the serum 25(OH)D and thyroid autoantibodies and thyroid nodules.[Results]The prevalence of deficiency in adult women was determined to be 69.31%.Alkaline phosphatase(ALP),low-density lipoprotein(LDL),anti-thyroglobulin antibodies(TGAB)and anti-thyroid peroxidase autoantibody(TPOAB)levels significantly differed between the severe deficiency group and sufficient group(each P<0.05).Moreover,prevalence of thyroid nodules,TGAB,TGAB and/or TPOAB differed significantly across the four groups(each P<0.05).Logistic regression analysis showed that decrease of serum 25(OH)D was significantly associated with age and increasing prevalence of thyroid nodules,TGAB,TGAB and/or TPOAB.[Conclusion]Vitamin D deficiency remains high in adult women for health examination in Shanghai.Serum 25(OH)D insufficiency or deficiency is associated with age,thyroid autoantibodies and thyroid nodules.