成都市ART耐药的HIV/AIDS患者焦虑抑郁状况及其影响因素

Prevalence and influencing factors of depression and anxiety among drug-resistant patients living with HIV/AIDS in Chengdu

目的了解成都市ART耐药的HIV/AIDS患者中焦虑和抑郁症状及其影响因素。方法采用横断面设计,对成都市ART耐药的HIV/AIDS患者进行问卷调查,收集其社会人口学资料及其他一般特征、社会资本、病耻感和疾病感知等信息,采用二分类非条件Logistic回归模型分析其焦虑和抑郁的影响因素。结果229名耐药患者中,19.65%(45/229)检出焦虑症状,21.83%(50/229)检出抑郁症状。多因素Logistic回归分析发现:女性(OR=2.40,95%CI:1.03~5.60)、19~35岁(OR=4.20,95%CI:1.44~12.25)、社会资本低(OR=0.34,95%CI:0.16~0.74)、病耻感高(OR=2.82,95%CI:1.25~6.35)、疾病感知高(OR=3.25,95%CI:1.45~7.27)的耐药患者更容易出现焦虑;确诊时长3~4年、≥5年(OR=3.68,95%CI:1.51~8.98、OR=2.72,95%CI:1.12~6.65),患基础性疾病(OR=2.26,95%CI:1.06~4.80)和病耻感高(OR=10.77,95%CI:4.62~25.11)的耐药患者更容易出现抑郁症状。结论成都市ART耐药患者中应重点关注女性、青年、社会资本低、患基础性疾病和确诊时间3年及以上的患者的心理健康状况。加强对耐药发生原因、后续治疗处置和治疗前景相关问题的解释和引导。

Objective To analyze the prevalence and influencing factors of depression and anxiety among drugresistant patients living with HIV/AIDS in Chengdu,Sichuan Province.Methods A cross-sectional survey was conducted among ART-resistant HIV/AIDS patients in Chengdu.Sociodemographic data,other general characteristics,social capital,perception of stigma,and disease perception were collected.A binary unconditional logistic regression model was used to analyze the influencing factors related to the depression and anxiety of subjects.Results A total of 229 patients were surveyed.The patients with anxiety accounted for 19.65%(45/229),while the patients with depression accounted for 21.83%(50/229).Multivariate logistic regression analysis showed that the drug-resistant patients with following characteristics were more likely to have anxiety symptoms:female(OR=2.40,95%CI:1.03-5.60),19-35 years old(OR=4.20,95%CI:1.44-12.25),lower social capital(OR=0.34,95%CI:0.16-0.74),higher perception of stigma(OR=2.82,95%CI:1.25-6.35)and disease perception(OR=3.25,95%CI:1.45-7.27).Patients with following characteristic were more likely to be susceptible to depression:HIV diagonosis duration lasts 3-4 years and≥5 years(OR=3.68,95%CI:1.51-8.98,OR=2.72,95%CI:1.12-6.65),having other diseases(OR=2.26,95%CI:1.06-4.80),higher perception of stigma(OR=10.7795%CI:4.62-25.11).Conclusions More attention should be paid to those drug-resistant patients living with HIV/AIDS,female,younger,with lower social capital,having an underlying disease and longer duration of infection.Strengthen the explanation of the causes,follow-up treatment,and treatment prospects to patients.