血清25-羟基维生素D与原发性BPPV相关性的分析

Analysis of correlation between serum 25-hydroxyvitamin D and primary BPPV

目的:探讨血清25-羟基维生素D﹝25-(OH)D﹞水平与原发性良性阵发性位置性眩晕(BPPV)发生及复发的相关性。方法:以2020年3月1日至2021年9月30日收治的75例确诊为原发性BPPV的患者为BPPV组,以同期健康体检的75例健康人为健康组。收集两组的血液标本,检测并比较其血清25-(OH)D的水平,总结血清25-(OH)D水平与原发性BPPV的关系,以及对本病复发的影响。结果:BPPV组血清25-(OH)D的平均水平为(21.45±9.24)ng/mL,健康组血清25-(OH)D的平均水平为(25.15±10.83)ng/mL,二者相比差异有统计学意义(P<0.05)。两组的年龄、性别、高血压发生率、糖尿病发生率比较,差异无统计学意义(P>0.05)。经单因素及多因素Logistic回归分析显示,血清25-(OH)D水平降低更易造成BPPV复发(P<0.05)。结论:血清25-(OH)D水平降低与BPPV的发生和复发有关,与其他基线指标无关。

Objective:To investigate the correlation between serum 25-(OH)D levels and the occurrence and recurrence of primary benign paroxysmal positional vertigo(BPPV).Methods:75 patients diagnosed with primary BPPV admitted from March 1,2020 to September 30,2021 were selected as the BPPV group,and 75 healthy patients who underwent physical examination during the same period were selected as the healthy group.The blood samples of the two groups were collected to detect and compare the serum 25-(OH)D level,and to summarize the relationship between the serum 25-(OH)D level and the primary BPPV,as well as the influence on the recurrence of the disease.Results:The average level of serum 25-(OH)D in BPPV group was(21.45±9.24)ng/mL,and the average level of serum 25-(OH)D in healthy group was(25.15±10.83)ng/mL,and the difference was statistically significant(P<0.05).There was no significant difference in age,sex,incidence of hypertension and incidence of diabetes between the two groups(P>0.05).Univariate and multivariate Logistic regression analysis showed that decreased serum 25-(OH)D level was more likely to cause BPPV recurrence(P<0.05).Conclusions:The decrease of serum 25-(OH)D level is associated with the occurrence and recurrence of BPPV,and is independent of other baseline indicators.