绝经后骨质疏松发生机制的研究进展

Research progress inthepathogenesisof postmenopausal osteoporosis

绝经后骨质疏松(PMO)患者因雌激素分泌下降导致骨量减少,骨微结构破坏,骨强度下降、脆性增加,易发生脆性骨折,严重影响患者的生活质量及生命健康。明确PMO的发生机制并对其进行有效的针对性防治可极大地改善患者的生活质量。PMO的发生除受到雌激素影响外,还与氧化应激、雌激素受体、机械力学刺激及成骨细胞中Piezo1基因表达关系极为密切。本文对以上要素进行综述,旨在进一步提高对PMO发生机制的认识。

Postmenopausal osteoporosis(PMO) patients are prone to brittle fracture due to decreased estrogen secretion, which leads to decreased bone mass, destruction of bone microstructure, decreased bone strength and increased fragility, and seriously affects the quality of life and health of patients.It can greatly improve the quality of life of patients to clarify the mechanism of PMO and carry out effective targeted prevention and treatment.The occurrence of PMO is not only affected by estrogen, but also closely related to oxidative stress, estrogen receptor, mechanical stimulation and the expression of Piezo1 gene in osteoblasts.This paper reviews the above elements, aiming to further improve the understanding of the mechanism of PMO.