镁的内稳态及其与心血管疾病相关性的研究进展

Research progress on homeostasis of magnesium and its correlation with cardiovascular diseases

镁是生物体中维持细胞正常生命活动不可缺少的电解质。镁离子(Mg^(2+))转运蛋白TRPM6/7、SLC41A1、MagT1和CNNM2/3/4等在转运镁的过程中发挥着重要作用。Mg^(2+)具有改善内皮功能、血管张力、外周血管阻力、心肌代谢、脂质代谢等功能,它还参与氧化应激及炎症反应的调节过程。镁缺乏会增加动脉粥样硬化、心律失常、高血压、2型糖尿病、胰岛素抵抗、代谢综合征等的发生风险。补充镁能降低血压、动脉硬化、空腹血糖、胰岛素抵抗和术后心律失常等的发生。膳食镁摄入增加可以降低心血管疾病和相关代谢病的发生风险。本文主要对Mg^(2+)的生物学作用及其与心血管疾病相关性的研究进展进行综述。

Magnesium is an indispensable electrolyte to maintain normal life activities of cells in living organisms.Magnesiumion(Mg^(2+))including TRPM6/7,SLC41A1,MagT1 and CNNM2/3/4 play important roles in magnesium ion transport.Mg^(2+)can improve endothelial function,vascular tone,peripheral vascular resistance,myocardial metabolism,lipid metabolism and other functions.It also involved in the regulation of oxidative stress and inflammation.Magnesium deficiency increases the risk of atherosclerosis,arrhythmias,hypertension,type 2 diabetes,insulin resistance,metabolic syndrome and more.Magnesium supplementation can reduce the incidence of blood pressure,arteriosclerosis,fasting blood glucose,insulin resistance and postoperative arrhythmia.Increased dietary magnesium intake may reduce the risk of cardiovascular disease and its associated metabolic diseases.This paper mainly reviews the recent researches on the biological effects of magnesium ion and its relationship with cardiovascular diseases.