基于数据挖掘的《医案类聚》痿证用药规律分析

Analysis on the rule of medication for flaccidity syndrome in "Yian Leiju" based on data mining

目的 分析挖掘《医案类聚》中治疗痿证医案中的用药规律,为痿证的临床治疗提供参考。方法 搜集整理《医案类聚》中古代医家的医案,根据纳入排除标准提取处方药物,进行规范化处理,应用古今医案云平台软件(V2.3.5)对处方数据进行频次统计、聚类分析、关联分析、复杂网络等分析,得到古代医家治疗痿证的用药规律。结果 经过筛选,共涉及医家38人,纳入医案157案,共166诊次,总用药频次1 596次。常用中药味多甘苦,主要归于肾、肝经,高频药物为当归、牛膝、茯苓,常用药对有当归-牛膝、虎胫骨-牛膝等,核心方药组成以虎潜丸为基础加减。结论 《医案类聚》中各医家治疗痿证的常用药物以补肝肾、强筋骨为主,清利湿热、调畅气机为辅,治疗以补益为主,以肝肾为本,辅以清热坚阴。

Objective To analyze the mid-term treatment rules of the treatment plan for flaccidity syndrome in the cluster "Yian Leiju" to provide references for future sputum related treatments. Method The medical cases of ancient physicians in "Yian Leiju" were collected and organized, and the prescription drugs were extracted according to the inclusion/exclusion criteria and standardized, and we applied the Ancient and Modern Consilia Cloud Platform Software(V2.3.5) to analyze the prescription data by frequency statistics, cluster analysis, correlation analysis, and complex network to obtain the medication patterns of ancient medical doctors for the treatment of flaccidity syndrome. Result After screening, a total of 38 doctors were involved, 157 medical cases were included, with 166 consultations, and the total frequency of 1596 times. Commonly used Chinese medicines taste more sweet and bitter,mainly attributed to the kidney, liver meridian, high frequency drugs for angelica, knee, Poria,common drugs for angelica-achyranthes bidentata, tiger tibia-achyranthes bidentata, etc.,the core prescription composition was based on Huqian Pills with addition and reduction.Conclusion In "Yian Leiju", the most commonly used drugs for treating flaccidity are mainly to tonify the liver and kidney, strengthen the muscles and bones supplemented by clearing away dampness and heat, and regulating qi. The treatment is based on the liver and kidneys and tonification, supplemented by clearing away heat and strengthening Yin.