重视老年人衰弱防治研究

Combating frailty in aging populations: switching to a more positive attitude in frailty research

衰弱是一种与增龄相关的易损状态,表现为抵抗应激的能力下降,可用于解释同龄人群衰老速度的异质性,特征是多个生理系统的储备和功能下降而表现出明显的脆弱性,并与不良后果相关,如跌倒、失能和死亡。该文呼吁重视对衰弱的流行病学研究、衰弱的社区和临床防治研究,以及“老年保护剂”抗衰弱的研究,促进研究转化,有助于开发新的防治措施,促进健康老龄化。

Frailty is a state of high vulnerability to adverse health outcomes, manifests as the inability to tolerate stressful events.This concept is used to explain the heterogeneity in rates of aging in people of the same age.Frailty has important clinical implications, because even minor stressors can lead to adverse outcomes, such as falls, disability, and mortality in frail individuals.In this article, we call for attaching importance to the epidemiological research, community and clinical prevention and treatment research of frailty, and highlight potential frailty interventions, such as geroprotectors.These exciting new developments in the field have the potential to facilitate translational research, and help develop new interventions to mitigate frailty in our aging population.