干预性抗菌药物预防骨科围术期感染的效果

Effect of Interventional Antibiotics on Preventing Perioperative Infection in Orthopedics

目的:分析干预性抗菌药物治疗预防骨科围术期感染的效果。方法:选取2021年7月-2022年7月江门市蓬江区中西医结合医院收治的手术患者90例为观察对象,根据随机数字表法分为观察组与对照组,各45例。对照组给予常规治疗,观察组在对照组基础上给予干预性抗菌药物治疗,比较两组患者治疗效果。结果:实施后,两组患者抗菌药物使用管理质量、医护人员对抗菌药物知识掌握度、患者遵医用药行为评分均升高,C反应蛋白(CRP)、红细胞沉降率(ESR)水平均下降,观察组抗菌药物使用管理质量、医护人员对抗菌药物知识掌握度、患者遵医用药行为评分高于对照组,CRP、ESR水平低于对照组,差异有统计学意义(P<0.05);观察组抗菌药物合理使用率高于对照组,切口感染发生率、用药不良反应发生率低于对照组,差异有统计学意义(P<0.05);观察组用药管理满意度高于对照组,差异有统计学意义(P<0.05)。结论:围术期开展干预性抗菌药物治疗骨科手术患者,可有效提高预防术后感染的效果,降低炎性因子水平,减少切口感染发生率,提高抗菌药物合理使用率,降低用药不良反应发生率。

Objective:To analyze the effect of interventional antimicrobial to prevent perioperative infection in orthopedics.Methods:A total of 90 surgical patients admitted to Pengjiang District Hospital of Integrated Traditional Chinese and Western Medicine from July 2021 to July 2022 were selected as observation objects,and were divided into observation group and control group according to random number table method,with 45 cases in each group.The control group was given routine treatment,and the observation group was given interventional antibacterial therapy on the basis of the control group.The therapeutic effect of the two groups was compared.Results:After implementation,the management quality of antibiotics,the knowledge of medical staff on antibiotics,the score of patients'compliance with medical drugs were increased in both groups,and the levels of C-reactive protein(CRP)and erythrocyte sedimentation rate(ESR)were decreased.The quality of antibiotics use management,the knowledge of antibiotics of medical staff and the scores of patients'compliance with medical drugs in observation group were higher than those in control group.The levels of CRP and ESR were lower than those of control group,and the difference was statistically significant(P<0.05).The rational utilization rate of antibiotics in the observation group was higher than that in the control group,and the incidence of incision infection and adverse drug reactions was lower than that in the control group,with statistical significance(P<0.05).The satisfaction of medication management in the observation group was higher than that in the control group,the difference was statistically significant(P<0.05).Conclusion:Perioperative intervention of antibiotics in orthopedic surgery patients can effectively improve the effect of postoperative infection prevention,reduce the level of inflammatory factors,reduce the incidence of incision infection,improve the rational utilization rate of antibiotics,and reduce the incidence of adverse drug reactions.